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Tanima SenGupta

Senior Scientist

+47 63 89 82 69

+47 938 59 683

Environmental Chemistry and Health Effects

Kjeller

tsen@nilu.no

Tanima Sengupta

Tanima SenGupta (PhD in Molecular Biology) is a Senior Scientist at NILU at the Health Effect Laboratory MILK. She has an extensive research background focused on DNA damage and repair, mutagenesis, mitochondrial dysfunction, DNA and RNA sequencing, gene expression analysis, epigenetic alterations, and cell death pathways. She also brings considerable experience in neurodegenerative diseases, including Parkinson’s disease and Alzheimer’s disease, with a dedicated focus on the molecular mechanisms underlying brain health and aging, alongside her work in cancer research. Her research integrates cross-model validation using human cell lines, C. elegans and mouse models to enhance translational relevance. In her 18 years of scientific career, she has published in several high-impact journals, including Nature Communications, Cell, Nature Biomedical Engineering, and Cell Reports.

At NILU, Tanima SenGupta has been actively involved in multidisciplinary EU research projects (including PROPLANET, ANALYST, GOTTARG, PARC, and NEXED) addressing complex challenges at the intersection of environmental and human health. Her current work focuses on the integrated hazard and risk assessment of genotoxicants, non-genotoxicants, chemical mixtures, and environmental pollutants, particularly those affecting ecosystems, air quality, and the plastic value chain. She employs a combination of human cell lines, advanced human in vitro models, and the bridging model C. elegans model to support mechanistic and translational insights. Her research is guided by frameworks such as Safe and Sustainable by Design (SSbD), the One Health approach, and OECD test guidelines, contributing to both regulatory science and sustainable innovation.

At NILU, she has also established a dedicated C. elegans laboratory facility to support the development of New Approach Methodologies (NAMs), where she focuses on reproductive and developmental toxicity of human and environmental toxicants.

In a new role, she serves as a co-supervisor for a doctoral candidate in the MSCA-funded NEXED program (started in 2025), contributing to the training and mentorship of the next generation of researchers in environmental and health sciences. Her work aims to generate novel mechanistic insights and promote cross-species endocrine disruption (ED) assessment, applying a One Health approach to bridge environmental and human health research.

Tanima SenGupta has 15 publications at NILU:

Application of the Comet Assay in Advanced In Vitro Models

Rundén-Pran, Elise; Yamani, Naouale El; Murugadoss, Sivakumar; Sengupta, Tanima; Longhin, Eleonora Marta; Olsen, Ann-Karin Hardie; Honza, Tatiana; Hudecova, Alexandra Misci; McFadden, Erin; Brochmann, Solveig; Ma, Xiaoxiong; Dusinska, Maria

2026

Towards a Safe and Sustainable Plastic Future: A Tiered Approach for Safety Assessment in the SSbD context

Sengupta, Tanima; Murugadoss, Sivakumar; Olsen, Ann-Karin Hardie; Yamani, Naouale El; Dusinska, Maria; Rundén-Pran, Elise; Longhin, Eleonora Marta

2025

CompSafeNano project: NanoInformatics approaches for safe-by-design nanomaterials

Zouraris, Dimitrios; Mavrogiorgis, Angelos; Tsoumanis, Andreas; Saarimaki, Laura Aliisa; Giudice, Giusy del; Federico, Antonio; Serra, Angela; Greco, Dario; Rouse, Ian; Subbotina, Julia; Lobaskin, Vladimir; Jagiello, Karolina; Ciura, Krzesimir; Judzinska, Beata; Mikolajczyk, Alicja; Sosnowska, Anita; Puzyn, Tomasz; Gulumian, Mary; Wepener, Victor; Martinez, Diego S. T.; Petry, Romana; Yamani, Naouale El; Rundén-Pran, Elise; Murugadoss, Sivakumar; Shaposhnikov, Sergey; Minadakis, Vasileios; Tsiros, Periklis; Sarimveis, Harry; Longhin, Eleonora Marta; Sengupta, Tanima; Olsen, Ann-Karin Hardie; Skakalova, Viera; Hutar, Peter; Dusinska, Maria; Papadiamantis, Anastasios; Gheorghe, L. Cristiana; Reilly, Katie; Brun, Emilie; Ullah, Sami; Cambier, Sebastien; Serchi, Tommaso; Tamm, Kaido; Lorusso, Candida; Dondero, Francesco; Melagrakis, Evangelos; Fraz, Muhammad Moazam; Melagraki, Georgia; Lynch, Iseult; Afantitis, Antreas

2025

Development of PFAS-free coatings following a Safe and Sustainable by Design (SSbD) approach – the PROPLANET project

Longhin, Eleonora Marta; Murugadoss, Sivakumar; SenGupta, Tanima; Yamani, Naouale El; McFadden, Erin; Honza, Tatiana; Ma, Xiaoxiong; Brochmann, Solveig; Verbič, Anja; Stres, Blaž; Novak, Uroš; Likozar, Blaž; Hudecova, Alexandra Misci; Olsen, Ann-Karin Hardie; Seif, Johannes P.; Dusinska, Maria; Rundén-Pran, Elise

2025

The ANALYST project: Strengthening the integrated approach of holistic impact assessments for Safe and Sustainable by design plastic value chain

Longhin, Eleonora Marta; Murugadoss, Sivakumar; Olsen, Ann-Karin Hardie; SenGupta, Tanima; Rundén-Pran, Elise; Yamani, Naouale El; Dusinska, Maria; Lago, Ana; Ferreira, G.

2025

New Approach Methods (NAMs) for genotoxicity assessment of nano- and advanced materials; Advantages and challenges

Gutleb, Arno; Murugadoss, Sivakumar; Stepnik, Maciej; SenGupta, Tanima; Yamani, Naouale El; Longhin, Eleonora Marta; Olsen, Ann-Karin Hardie; Wyrzykowska, Ewelina; Jagiello, Karolina; Judzinska, Beata; Cambier, Sebastien; Honza, Tatiana; McFadden, Erin; Shaposhnikov, Sergey; Puzyn, Tomasz; Serchi, Tommaso; Weber, Pamina; Arnesdotter, Emma; Skakalova, Vier; Jirsova, Katerina; Grudzinski, Ireneusz; Collins, Andrew; Rundén-Pran, Elise; Dusinska, Maria

2025

Development of PFAS-free coatings in the safe and sustainable by design (SSbD) framework – the PROPLANET project

Yamani, Naouale El; Murugadoss, Sivakumar; McFadden, Erin; Honza, Tatiana; Sengupta, Tanima; Ma, Xiaoxiong; Brochmann, Solveig; Varsou, Dimitra Danai; Afantitis, Antreas; Seif, Johannes P.; Dusinska, Maria; Rundén-Pran, Elise; Longhin, Eleonora Marta

2024

Recent advances and current challenges of new approach methodologies in developmental and adult neurotoxicity testing

Serafini, Melania Maria; Sepheri, Sara; Midali, Miriam; Stinckens, Marth; Biesiekierska, Marta; Wolniakowska, Anna; Gatzios, Alexandra; Rundén-Pran, Elise; Reszka, Edyta; Marinovich, Marina; Vanhaecke, Tamara; Roszak, Joanna; Viviani, Barbara; SenGupta, Tanima

2024

The Role of DNA repair in aging and neurodegeneration

SenGupta, Tanima; Nilsen, Hilde Loge; Rundén-Pran, Elise

2024

Development of PFAS-free coatings in a safe and sustainable by design (SSbD) approach- the PROPLANET project

Longhin, Eleonora Marta; Varsou, Dimitra Danai; McFadden, Erin; Honza, Tatiana; SenGupta, Tanima; Murugadoss, Sivakumar; Brochmann, Solveig; Afantitis, Antreas; Dusinska, Maria; Rundén-Pran, Elise

2024

Preclinical validation of human recombinant glutamate-oxaloacetate transaminase for the treatment of acute ischemic stroke

Pérez-Mato, María; Dopico-López, Antonio; Akkoc, Yunus; López-Amoedo, Sonia; Correa-Paz, Clara; Candamo-Lourido, María; Iglesias-Rey, Ramón; López-Arias, Esteban; Bugallo-Casal, Ana; Silva-Candal, Andrés da; Bravo, Susana B.; Chantada-Vázquez, María del Pilar; Arias, Susana; Santamaría-Cadavid, María; Estany-Gestal, Ana; Zaghmi, Ahlem; Gauthier, Marc A.; Gutiérrez-Fernández, María; Martin, Abraham; Llop, Jordi; Rodríguez, Cristina; Almeida, Ángeles; Migliavacca, Martina; Polo, Ester; Pelaz, Beatriz; Gozuacik, Devrim; Yamani, Naouale El; Sengupta, Tanima; Rundén-Pran, Elise; Vivancos, José; Castellanos, Mar; Díez-Tejedor, Exuperio; Sobrino, Tomás; Rabinkov, Aharon; Mirelman, David; Castillo, José; Campos, Francisco

2024

Hazard assessment methodologies applicable to the SSbD framework: where we are

Longhin, Eleonora Marta; Murugadoss, Sivakumar; Olsen, Ann-Karin Hardie; SenGupta, Tanima; Rundén-Pran, Elise; Dusinska, Maria

2024

Can we identify safe(r) substitutes for PFAS coatings?

Longhin, Eleonora Marta; Olsen, Ann-Karin Hardie; Varsou, Dimitra Danai; McFadden, Erin; Ma, Xiaoxiong; Honza, Tatiana; SenGupta, Tanima; Yamani, Naouale El; Murugadoss, Sivakumar; Brochmann, Solveig; Afantitis, Antreas; Dusinska, Maria; Rundén-Pran, Elise; Seif, Johannes P.; Torres, Alejandro Del Real

2024

C. elegans as a Model System for Assessing Neurotoxicity

SenGupta, Tanima; Dusinska, Maria; Rundén-Pran, Elise

2023

Glutamate Oxaloacetate Transaminase Nanoparticles: A Promising Novel Therapy for Ischemic Stroke

SenGupta, Tanima; Mariussen, Espen; Yamani, Naouale El; Honza, Tatiana; McFadden, Erin; Dusinska, Maria; Rundén-Pran, Elise; Gauthier, Marc A.

2023

Strengthening the integrated approach of holistic impact assessments for Safe and Sustainable by Design plastic value chain (ANALYST)

ANALYST aims to accelerate the transition towards a safer and more sustainable industrial value chain while encouraging and expanding the existing knowledge on the safe and sustainable by design (SSbD) […]

Project period: 2024 – 2027

Ongoing

Enhanced Safe and Sustainable coatings for supporting the Planet (PROPLANET)

PROPLANET addresses novel coating materials solutions, tackling the problem from a sustainable-business perspective, enabling overcoming the barrier for environmental protection, safety, chemical improvements, and circular value chains. The main goal […]

Project period: 2023 – 2026

Ongoing

Tanima SenGupta (PhD in Molecular Biology) is a Senior Scientist at NILU at the Health Effect Laboratory MILK. She has an extensive research background focused on DNA damage and repair, mutagenesis, mitochondrial dysfunction, DNA and RNA sequencing, gene expression analysis, epigenetic alterations, and cell death pathways. She also brings considerable experience in neurodegenerative diseases, including Parkinson’s disease and Alzheimer’s disease, with a dedicated focus on the molecular mechanisms underlying brain health and aging, alongside her work in cancer research. Her research integrates cross-model validation using human cell lines, C. elegans and mouse models to enhance translational relevance. In her 18 years of scientific career, she has published in several high-impact journals, including Nature Communications, Cell, Nature Biomedical Engineering, and Cell Reports.

At NILU, Tanima SenGupta has been actively involved in multidisciplinary EU research projects (including PROPLANET, ANALYST, GOTTARG, PARC, and NEXED) addressing complex challenges at the intersection of environmental and human health. Her current work focuses on the integrated hazard and risk assessment of genotoxicants, non-genotoxicants, chemical mixtures, and environmental pollutants, particularly those affecting ecosystems, air quality, and the plastic value chain. She employs a combination of human cell lines, advanced human in vitro models, and the bridging model C. elegans model to support mechanistic and translational insights. Her research is guided by frameworks such as Safe and Sustainable by Design (SSbD), the One Health approach, and OECD test guidelines, contributing to both regulatory science and sustainable innovation.

At NILU, she has also established a dedicated C. elegans laboratory facility to support the development of New Approach Methodologies (NAMs), where she focuses on reproductive and developmental toxicity of human and environmental toxicants.

In a new role, she serves as a co-supervisor for a doctoral candidate in the MSCA-funded NEXED program (started in 2025), contributing to the training and mentorship of the next generation of researchers in environmental and health sciences. Her work aims to generate novel mechanistic insights and promote cross-species endocrine disruption (ED) assessment, applying a One Health approach to bridge environmental and human health research.

Tanima SenGupta has 15 publications at NILU:

Application of the Comet Assay in Advanced In Vitro Models

Rundén-Pran, Elise; Yamani, Naouale El; Murugadoss, Sivakumar; Sengupta, Tanima; Longhin, Eleonora Marta; Olsen, Ann-Karin Hardie; Honza, Tatiana; Hudecova, Alexandra Misci; McFadden, Erin; Brochmann, Solveig; Ma, Xiaoxiong; Dusinska, Maria

2026

Towards a Safe and Sustainable Plastic Future: A Tiered Approach for Safety Assessment in the SSbD context

Sengupta, Tanima; Murugadoss, Sivakumar; Olsen, Ann-Karin Hardie; Yamani, Naouale El; Dusinska, Maria; Rundén-Pran, Elise; Longhin, Eleonora Marta

2025

CompSafeNano project: NanoInformatics approaches for safe-by-design nanomaterials

Zouraris, Dimitrios; Mavrogiorgis, Angelos; Tsoumanis, Andreas; Saarimaki, Laura Aliisa; Giudice, Giusy del; Federico, Antonio; Serra, Angela; Greco, Dario; Rouse, Ian; Subbotina, Julia; Lobaskin, Vladimir; Jagiello, Karolina; Ciura, Krzesimir; Judzinska, Beata; Mikolajczyk, Alicja; Sosnowska, Anita; Puzyn, Tomasz; Gulumian, Mary; Wepener, Victor; Martinez, Diego S. T.; Petry, Romana; Yamani, Naouale El; Rundén-Pran, Elise; Murugadoss, Sivakumar; Shaposhnikov, Sergey; Minadakis, Vasileios; Tsiros, Periklis; Sarimveis, Harry; Longhin, Eleonora Marta; Sengupta, Tanima; Olsen, Ann-Karin Hardie; Skakalova, Viera; Hutar, Peter; Dusinska, Maria; Papadiamantis, Anastasios; Gheorghe, L. Cristiana; Reilly, Katie; Brun, Emilie; Ullah, Sami; Cambier, Sebastien; Serchi, Tommaso; Tamm, Kaido; Lorusso, Candida; Dondero, Francesco; Melagrakis, Evangelos; Fraz, Muhammad Moazam; Melagraki, Georgia; Lynch, Iseult; Afantitis, Antreas

2025

Development of PFAS-free coatings following a Safe and Sustainable by Design (SSbD) approach – the PROPLANET project

Longhin, Eleonora Marta; Murugadoss, Sivakumar; SenGupta, Tanima; Yamani, Naouale El; McFadden, Erin; Honza, Tatiana; Ma, Xiaoxiong; Brochmann, Solveig; Verbič, Anja; Stres, Blaž; Novak, Uroš; Likozar, Blaž; Hudecova, Alexandra Misci; Olsen, Ann-Karin Hardie; Seif, Johannes P.; Dusinska, Maria; Rundén-Pran, Elise

2025

The ANALYST project: Strengthening the integrated approach of holistic impact assessments for Safe and Sustainable by design plastic value chain

Longhin, Eleonora Marta; Murugadoss, Sivakumar; Olsen, Ann-Karin Hardie; SenGupta, Tanima; Rundén-Pran, Elise; Yamani, Naouale El; Dusinska, Maria; Lago, Ana; Ferreira, G.

2025

New Approach Methods (NAMs) for genotoxicity assessment of nano- and advanced materials; Advantages and challenges

Gutleb, Arno; Murugadoss, Sivakumar; Stepnik, Maciej; SenGupta, Tanima; Yamani, Naouale El; Longhin, Eleonora Marta; Olsen, Ann-Karin Hardie; Wyrzykowska, Ewelina; Jagiello, Karolina; Judzinska, Beata; Cambier, Sebastien; Honza, Tatiana; McFadden, Erin; Shaposhnikov, Sergey; Puzyn, Tomasz; Serchi, Tommaso; Weber, Pamina; Arnesdotter, Emma; Skakalova, Vier; Jirsova, Katerina; Grudzinski, Ireneusz; Collins, Andrew; Rundén-Pran, Elise; Dusinska, Maria

2025

Development of PFAS-free coatings in the safe and sustainable by design (SSbD) framework – the PROPLANET project

Yamani, Naouale El; Murugadoss, Sivakumar; McFadden, Erin; Honza, Tatiana; Sengupta, Tanima; Ma, Xiaoxiong; Brochmann, Solveig; Varsou, Dimitra Danai; Afantitis, Antreas; Seif, Johannes P.; Dusinska, Maria; Rundén-Pran, Elise; Longhin, Eleonora Marta

2024

Recent advances and current challenges of new approach methodologies in developmental and adult neurotoxicity testing

Serafini, Melania Maria; Sepheri, Sara; Midali, Miriam; Stinckens, Marth; Biesiekierska, Marta; Wolniakowska, Anna; Gatzios, Alexandra; Rundén-Pran, Elise; Reszka, Edyta; Marinovich, Marina; Vanhaecke, Tamara; Roszak, Joanna; Viviani, Barbara; SenGupta, Tanima

2024

The Role of DNA repair in aging and neurodegeneration

SenGupta, Tanima; Nilsen, Hilde Loge; Rundén-Pran, Elise

2024

Development of PFAS-free coatings in a safe and sustainable by design (SSbD) approach- the PROPLANET project

Longhin, Eleonora Marta; Varsou, Dimitra Danai; McFadden, Erin; Honza, Tatiana; SenGupta, Tanima; Murugadoss, Sivakumar; Brochmann, Solveig; Afantitis, Antreas; Dusinska, Maria; Rundén-Pran, Elise

2024

Preclinical validation of human recombinant glutamate-oxaloacetate transaminase for the treatment of acute ischemic stroke

Pérez-Mato, María; Dopico-López, Antonio; Akkoc, Yunus; López-Amoedo, Sonia; Correa-Paz, Clara; Candamo-Lourido, María; Iglesias-Rey, Ramón; López-Arias, Esteban; Bugallo-Casal, Ana; Silva-Candal, Andrés da; Bravo, Susana B.; Chantada-Vázquez, María del Pilar; Arias, Susana; Santamaría-Cadavid, María; Estany-Gestal, Ana; Zaghmi, Ahlem; Gauthier, Marc A.; Gutiérrez-Fernández, María; Martin, Abraham; Llop, Jordi; Rodríguez, Cristina; Almeida, Ángeles; Migliavacca, Martina; Polo, Ester; Pelaz, Beatriz; Gozuacik, Devrim; Yamani, Naouale El; Sengupta, Tanima; Rundén-Pran, Elise; Vivancos, José; Castellanos, Mar; Díez-Tejedor, Exuperio; Sobrino, Tomás; Rabinkov, Aharon; Mirelman, David; Castillo, José; Campos, Francisco

2024

Hazard assessment methodologies applicable to the SSbD framework: where we are

Longhin, Eleonora Marta; Murugadoss, Sivakumar; Olsen, Ann-Karin Hardie; SenGupta, Tanima; Rundén-Pran, Elise; Dusinska, Maria

2024

Can we identify safe(r) substitutes for PFAS coatings?

Longhin, Eleonora Marta; Olsen, Ann-Karin Hardie; Varsou, Dimitra Danai; McFadden, Erin; Ma, Xiaoxiong; Honza, Tatiana; SenGupta, Tanima; Yamani, Naouale El; Murugadoss, Sivakumar; Brochmann, Solveig; Afantitis, Antreas; Dusinska, Maria; Rundén-Pran, Elise; Seif, Johannes P.; Torres, Alejandro Del Real

2024

C. elegans as a Model System for Assessing Neurotoxicity

SenGupta, Tanima; Dusinska, Maria; Rundén-Pran, Elise

2023

Glutamate Oxaloacetate Transaminase Nanoparticles: A Promising Novel Therapy for Ischemic Stroke

SenGupta, Tanima; Mariussen, Espen; Yamani, Naouale El; Honza, Tatiana; McFadden, Erin; Dusinska, Maria; Rundén-Pran, Elise; Gauthier, Marc A.

2023

Strengthening the integrated approach of holistic impact assessments for Safe and Sustainable by Design plastic value chain (ANALYST)

ANALYST aims to accelerate the transition towards a safer and more sustainable industrial value chain while encouraging and expanding the existing knowledge on the safe and sustainable by design (SSbD) […]

Project period: 2024 – 2027

Ongoing

Enhanced Safe and Sustainable coatings for supporting the Planet (PROPLANET)

PROPLANET addresses novel coating materials solutions, tackling the problem from a sustainable-business perspective, enabling overcoming the barrier for environmental protection, safety, chemical improvements, and circular value chains. The main goal […]

Project period: 2023 – 2026

Ongoing