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Sivakumar Murugadoss

Scientist

+47 63 89 82 71

+47 403 04 310

Environmental Chemistry and Health Effects

Kjeller

siva@nilu.no

Dr. Sivakumar Murugadoss is a Scientist at NILU in the department of Environmental Chemistry and Health Effects. He specializes in toxicology, nanotoxicology, in vitro methods, Adverse Outcome Pathways (AOPs), Integrated Approaches to Testing and Assessment (IATA), and Safety-by-Design (SbD) concepts. He has served on the OECD Advisory Group on Emerging Science in Chemicals Assessment (ESCA) and the Belgian Society of Toxicology and Ecotoxicology (BelTox), contributing to international efforts to advance science-based chemical safety assessment.

Since joining NILU in 2024, he has worked on Horizon Europe projects such as ANALYST and PROPLANET, focusing on safe and sustainable PFAS-free coatings and plastics. His work applies Safe and Sustainable by Design (SSbD) principles to define safety frameworks and contribute to the development of practical toolboxes for integrated, holistic SSbD assessment – supported by his expertise in hazard assessment, mechanistic in vitro toxicity, and new approach methodologies (NAMs). He is also expanding his capabilities in in silico and exposure modelling tools to strengthen early-stage SSbD evaluations.

He has contributed to several EU-funded projects, focusing on the integration of mechanistic toxicology, regulatory science, and safety considerations to enable next-generation hazard assessment and the design of safer, more sustainable chemicals and materials.

Sivakumar Murugadoss has 18 publications at NILU:

CompSafeNano project: NanoInformatics approaches for safe-by-design nanomaterials

Zouraris, Dimitrios; Mavrogiorgis, Angelos; Tsoumanis, Andreas; Saarimaki, Laura Aliisa; Giudice, Giusy del; Federico, Antonio; Serra, Angela; Greco, Dario; Rouse, Ian; Subbotina, Julia; Lobaskin, Vladimir; Jagiello, Karolina; Ciura, Krzesimir; Judzinska, Beata; Mikolajczyk, Alicja; Sosnowska, Anita; Puzyn, Tomasz; Gulumian, Mary; Wepener, Victor; Martinez, Diego S. T.; Petry, Romana; Yamani, Naouale El; Rundén-Pran, Elise; Murugadoss, Sivakumar; Shaposhnikov, Sergey; Minadakis, Vasileios; Tsiros, Periklis; Sarimveis, Harry; Longhin, Eleonora Marta; Sengupta, Tanima; Olsen, Ann-Karin Hardie; Skakalova, Viera; Hutar, Peter; Dusinska, Maria; Papadiamantis, Anastasios; Gheorghe, L. Cristiana; Reilly, Katie; Brun, Emilie; Ullah, Sami; Cambier, Sebastien; Serchi, Tommaso; Tamm, Kaido; Lorusso, Candida; Dondero, Francesco; Melagrakis, Evangelos; Fraz, Muhammad Moazam; Melagraki, Georgia; Lynch, Iseult; Afantitis, Antreas

2025

Scientific journal publication

Development of PFAS-free coatings following a Safe and Sustainable by Design (SSbD) approach – the PROPLANET project

Longhin, Eleonora Marta; Murugadoss, Sivakumar; SenGupta, Tanima; Yamani, Naouale El; McFadden, Erin; Honza, Tatiana; Ma, Xiaoxiong; Brochmann, Solveig; Verbič, Anja; Stres, Blaž; Novak, Uroš; Likozar, Blaž; Hudecova, Alexandra Misci; Olsen, Ann-Karin Hardie; Seif, Johannes P.; Dusinska, Maria; Rundén-Pran, Elise

2025

Poster

The ANALYST project: Strengthening the integrated approach of holistic impact assessments for Safe and Sustainable by design plastic value chain

Longhin, Eleonora Marta; Murugadoss, Sivakumar; Olsen, Ann-Karin Hardie; SenGupta, Tanima; Rundén-Pran, Elise; Yamani, Naouale El; Dusinska, Maria; Lago, Ana; Ferreira, G.

2025

Poster

New Approach Methods (NAMs) for genotoxicity assessment of nano- and advanced materials; Advantages and challenges

Gutleb, Arno; Murugadoss, Sivakumar; Stepnik, Maciej; SenGupta, Tanima; Yamani, Naouale El; Longhin, Eleonora Marta; Olsen, Ann-Karin Hardie; Wyrzykowska, Ewelina; Jagiello, Karolina; Judzinska, Beata; Cambier, Sebastien; Honza, Tatiana; McFadden, Erin; Shaposhnikov, Sergey; Puzyn, Tomasz; Serchi, Tommaso; Weber, Pamina; Arnesdotter, Emma; Skakalova, Vier; Jirsova, Katerina; Grudzinski, Ireneusz; Collins, Andrew; Rundén-Pran, Elise; Dusinska, Maria

2025

Scientific journal publication

Advancing Genotoxicity Assessment by Building a Global AOP Network

Demuynck, Emmanuel; Vanhaecke, Tamara; Thienpont, Anouck; Cappoen, Davie; Goethem, Freddy Van; Winkelman, L. M. T.; Beltman, Joost B.; Murugadoss, Sivakumar; Olsen, Ann-Karin Hardie; Marcon, Francesca; Bossa, Cecilia; Shaikh, Sanah M.; Nikolopoulou, Dimitra; Hatzi, Vasiliki; Pennings, Jeroen L A; Luijten, Mirjam; Adam-Guillermin, Christelle; Paparella, Martin; Audebert, Marc; Mertens, Birgit

2025

Scientific journal publication

Applying Adverse Outcome Pathways to evaluate the Health Impact of Environmental Chemicals

Murugadoss, Sivakumar; Rundén-Pran, Elise; Dusinska, Maria

2024

Lecture

AOP development, the AOP wiki & the way to OECD endorsement

Murugadoss, Sivakumar

2024

Lecture

Development of PFAS-free coatings in a safe and sustainable by design (SSbD) approach- the PROPLANET project

Longhin, Eleonora Marta; Varsou, Dimitra Danai; McFadden, Erin; Honza, Tatiana; SenGupta, Tanima; Murugadoss, Sivakumar; Brochmann, Solveig; Afantitis, Antreas; Dusinska, Maria; Rundén-Pran, Elise

2024

Poster

Hazard assessment methodologies applicable to the SSbD framework: where we are

Longhin, Eleonora Marta; Murugadoss, Sivakumar; Olsen, Ann-Karin Hardie; SenGupta, Tanima; Rundén-Pran, Elise; Dusinska, Maria

2024

Poster

Can we identify safe(r) substitutes for PFAS coatings?

Longhin, Eleonora Marta; Olsen, Ann-Karin Hardie; Varsou, Dimitra Danai; McFadden, Erin; Ma, Xiaoxiong; Honza, Tatiana; SenGupta, Tanima; Yamani, Naouale El; Murugadoss, Sivakumar; Brochmann, Solveig; Afantitis, Antreas; Dusinska, Maria; Rundén-Pran, Elise; Seif, Johannes P.; Torres, Alejandro Del Real

2024

Poster

DNA damaging effects of occupational exposure to glass fibres. Response to Madl and Keeton paper

Ceppi, Marcello; Smolkova, Bozena; Buocikova, Verona; Rundén-Pran, Elise; Yamani, Naouale El; Longhin, Eleonora Marta; Murugadoss, Sivakumar; Staruchova, Marta; Barancokova, Magdalena; Volkovova, Katarina; Halašová, Erika; Kyrtopoulos, Soterios; Bonassi, Stefano; Collins, Andrew Richard Sherman; Dusinska, Maria

2024

Journal publication

Linking nanomaterial-induced mitochondrial dysfunction to existing adverse outcome pathways for chemicals

Murugadoss, Sivakumar; Vinković Vrček, Ivana; Schaffert, Alexandra; Paparella, Martin; Pem, Barbara; Sosnowska, Anita; Stępnik, Maciej; Martens, Marvin; Willighagen, Egon L.; Puzyn, Tomasz; Cimpan, Mihaela Roxana; Lemaire, Frauke; Mertens, Birgit; Dusinska, Maria; Fessard, Valérie; Hoet, Peter H.

2024

Scientific journal publication

Linking Nanomaterial-Induced Mitochondrial Dysfunction to Existing Adverse Outcome Pathways for Chemicals

Murugadoss, Sivakumar; Vrček, Ivana Vinković; Schaffert, Alexandra; Paparella, Martin; Pem, Barbara; Sosnowska, Anita; Stępnik, Maciej; Martens, Marvin; Willighagen, Egon L.; Puzyn, Tomasz; Cimpan, Mihaela-Roxana; Lemaire, Frauke; Mertens, Birgit; Dusinska, Maria; Fessard, Valérie; Hoet, Peter H.

2023

Scientific journal publication

Towards risk governance of nanomaterials: adaptation and validation of test methods for characterization and hazard assessment

Longhin, Eleonora Marta; Doak, Shareen H.; Lynch, Iseult; Moschini, Elisa; Rundén-Pran, Elise; Yamani, Naouale El; Bouman, Evert; Burgum, Michael J.; Reilly, Katie; Cambier, Sebastien; Gutleb, Arno C.; Cimpan, Mihaela-Roxana; Rios-Mondragon, Ivan; Xue, Ying; Cimpan, Emil; Puzyn, Tomasz; Sosnowska, Anita; Fessard, Valérie; Varet, Julie; Vrček, Ivana Vinković; Pem, Barbara; Fuente, Jesus Martinez de la; Castillo, Victor Manuel Sánchez del; Ayllón, Carlos Cuestas; Hoet, Peter; Murugadoss, Sivakumar; Nunes, Juliana de Souza; Lopez, Aitziber; Dupin, Damien; Ghahremani, MH; Gharailou, D; Badetti, Elena; Brunelli, Andrea; Isigonis, Panagiotis; Afantitis, Antreas; Melagraki, Georgia; Bohmer, Nils; Malsch, Ineke; Dusinska, Maria

2022

Lecture

A strategy towards the generation of testable adverse outcome pathways for nanomaterials

Murugadoss, Sivakumar; Vrcek, Ivana Vinkovic; Pem, Barbara; Jagiello, Karolina; Judzinska, Beata; Sosnowska, Anita; Martens, Marvin; Willighagen, Egon L.; Puzyn, Tomasz; Dusinska, Maria; Cimpan, Mihaela-Roxana; Fessard, Valérie; Hoet, Peter H.

2021

Scientific journal publication

Identifying the relevance of existing adverse outcome pathways for nanomaterials

Murugadoss, Sivakumar; Vrček, Ivana Vinković; Cimpan, Mihaela-Roxana; Pem, Barbara; Martens, Marvin; Willihagen, Egon; Sosnowska, Anita; Puzyn, Tomasz; Dusinska, Maria; Fessard, Valérie; Hoet, Peter

2021

Poster

Development of an Adverse Outcome Pathway for Chronic and Multi-Generational Impacts of Nanomaterials in the Environmental Indicator Species Daphnia Magna

Lynch, Iseult; Reilly, Katie; Cimpan, Mihaela Roxana; Drønen, Anne-Marthe; Rios-Mondragon, Ivan; Cambier, Sébastien; Gutleb, Arno; Serchi, Tommaso; Dusinska, Maria; Rundén-Pran, Elise; Mariussen, Espen; Longhin, Eleonora Marta; Murugadoss, Sivakumar; Hoet, Peter; Willihagen, Egon; Martens, Marvin; Afantitis, Antreas; Melargakis, Georgia; Vrcek, Ivana Vincovik

2020

Lecture

Generation of testable adverse outcome pathways (AOPs) for nanomaterial human hazard assessment

Murugadoss, Sivakumar; Vrcek, Ivana Vincovik; Cimpan, Mihaela-Roxana; Martens, Marvin; Gromelski, Maciej; Puzyn, Tomasz; Fessard, Valérie; Lynch, Iseult; Dusinska, Maria; Hoet, Peter

2020

Lecture

Strengthening the integrated approach of holistic impact assessments for Safe and Sustainable by Design plastic value chain (ANALYST)

ANALYST aims to accelerate the transition towards a safer and more sustainable industrial value chain while encouraging and expanding the existing knowledge on the safe and sustainable by design (SSbD) […]

Project period: 2024 – 2027

Ongoing

Enhanced Safe and Sustainable coatings for supporting the Planet (PROPLANET)

PROPLANET addresses novel coating materials solutions, tackling the problem from a sustainable-business perspective, enabling overcoming the barrier for environmental protection, safety, chemical improvements, and circular value chains. The main goal […]

Project period: 2023 – 2026

Ongoing

Dr. Sivakumar Murugadoss is a Scientist at NILU in the department of Environmental Chemistry and Health Effects. He specializes in toxicology, nanotoxicology, in vitro methods, Adverse Outcome Pathways (AOPs), Integrated Approaches to Testing and Assessment (IATA), and Safety-by-Design (SbD) concepts. He has served on the OECD Advisory Group on Emerging Science in Chemicals Assessment (ESCA) and the Belgian Society of Toxicology and Ecotoxicology (BelTox), contributing to international efforts to advance science-based chemical safety assessment.

Since joining NILU in 2024, he has worked on Horizon Europe projects such as ANALYST and PROPLANET, focusing on safe and sustainable PFAS-free coatings and plastics. His work applies Safe and Sustainable by Design (SSbD) principles to define safety frameworks and contribute to the development of practical toolboxes for integrated, holistic SSbD assessment – supported by his expertise in hazard assessment, mechanistic in vitro toxicity, and new approach methodologies (NAMs). He is also expanding his capabilities in in silico and exposure modelling tools to strengthen early-stage SSbD evaluations.

He has contributed to several EU-funded projects, focusing on the integration of mechanistic toxicology, regulatory science, and safety considerations to enable next-generation hazard assessment and the design of safer, more sustainable chemicals and materials.

Sivakumar Murugadoss has 18 publications at NILU:

CompSafeNano project: NanoInformatics approaches for safe-by-design nanomaterials

Zouraris, Dimitrios; Mavrogiorgis, Angelos; Tsoumanis, Andreas; Saarimaki, Laura Aliisa; Giudice, Giusy del; Federico, Antonio; Serra, Angela; Greco, Dario; Rouse, Ian; Subbotina, Julia; Lobaskin, Vladimir; Jagiello, Karolina; Ciura, Krzesimir; Judzinska, Beata; Mikolajczyk, Alicja; Sosnowska, Anita; Puzyn, Tomasz; Gulumian, Mary; Wepener, Victor; Martinez, Diego S. T.; Petry, Romana; Yamani, Naouale El; Rundén-Pran, Elise; Murugadoss, Sivakumar; Shaposhnikov, Sergey; Minadakis, Vasileios; Tsiros, Periklis; Sarimveis, Harry; Longhin, Eleonora Marta; Sengupta, Tanima; Olsen, Ann-Karin Hardie; Skakalova, Viera; Hutar, Peter; Dusinska, Maria; Papadiamantis, Anastasios; Gheorghe, L. Cristiana; Reilly, Katie; Brun, Emilie; Ullah, Sami; Cambier, Sebastien; Serchi, Tommaso; Tamm, Kaido; Lorusso, Candida; Dondero, Francesco; Melagrakis, Evangelos; Fraz, Muhammad Moazam; Melagraki, Georgia; Lynch, Iseult; Afantitis, Antreas

2025

Scientific journal publication

Development of PFAS-free coatings following a Safe and Sustainable by Design (SSbD) approach – the PROPLANET project

Longhin, Eleonora Marta; Murugadoss, Sivakumar; SenGupta, Tanima; Yamani, Naouale El; McFadden, Erin; Honza, Tatiana; Ma, Xiaoxiong; Brochmann, Solveig; Verbič, Anja; Stres, Blaž; Novak, Uroš; Likozar, Blaž; Hudecova, Alexandra Misci; Olsen, Ann-Karin Hardie; Seif, Johannes P.; Dusinska, Maria; Rundén-Pran, Elise

2025

Poster

The ANALYST project: Strengthening the integrated approach of holistic impact assessments for Safe and Sustainable by design plastic value chain

Longhin, Eleonora Marta; Murugadoss, Sivakumar; Olsen, Ann-Karin Hardie; SenGupta, Tanima; Rundén-Pran, Elise; Yamani, Naouale El; Dusinska, Maria; Lago, Ana; Ferreira, G.

2025

Poster

New Approach Methods (NAMs) for genotoxicity assessment of nano- and advanced materials; Advantages and challenges

Gutleb, Arno; Murugadoss, Sivakumar; Stepnik, Maciej; SenGupta, Tanima; Yamani, Naouale El; Longhin, Eleonora Marta; Olsen, Ann-Karin Hardie; Wyrzykowska, Ewelina; Jagiello, Karolina; Judzinska, Beata; Cambier, Sebastien; Honza, Tatiana; McFadden, Erin; Shaposhnikov, Sergey; Puzyn, Tomasz; Serchi, Tommaso; Weber, Pamina; Arnesdotter, Emma; Skakalova, Vier; Jirsova, Katerina; Grudzinski, Ireneusz; Collins, Andrew; Rundén-Pran, Elise; Dusinska, Maria

2025

Scientific journal publication

Advancing Genotoxicity Assessment by Building a Global AOP Network

Demuynck, Emmanuel; Vanhaecke, Tamara; Thienpont, Anouck; Cappoen, Davie; Goethem, Freddy Van; Winkelman, L. M. T.; Beltman, Joost B.; Murugadoss, Sivakumar; Olsen, Ann-Karin Hardie; Marcon, Francesca; Bossa, Cecilia; Shaikh, Sanah M.; Nikolopoulou, Dimitra; Hatzi, Vasiliki; Pennings, Jeroen L A; Luijten, Mirjam; Adam-Guillermin, Christelle; Paparella, Martin; Audebert, Marc; Mertens, Birgit

2025

Scientific journal publication

Applying Adverse Outcome Pathways to evaluate the Health Impact of Environmental Chemicals

Murugadoss, Sivakumar; Rundén-Pran, Elise; Dusinska, Maria

2024

Lecture

AOP development, the AOP wiki & the way to OECD endorsement

Murugadoss, Sivakumar

2024

Lecture

Development of PFAS-free coatings in a safe and sustainable by design (SSbD) approach- the PROPLANET project

Longhin, Eleonora Marta; Varsou, Dimitra Danai; McFadden, Erin; Honza, Tatiana; SenGupta, Tanima; Murugadoss, Sivakumar; Brochmann, Solveig; Afantitis, Antreas; Dusinska, Maria; Rundén-Pran, Elise

2024

Poster

Hazard assessment methodologies applicable to the SSbD framework: where we are

Longhin, Eleonora Marta; Murugadoss, Sivakumar; Olsen, Ann-Karin Hardie; SenGupta, Tanima; Rundén-Pran, Elise; Dusinska, Maria

2024

Poster

Can we identify safe(r) substitutes for PFAS coatings?

Longhin, Eleonora Marta; Olsen, Ann-Karin Hardie; Varsou, Dimitra Danai; McFadden, Erin; Ma, Xiaoxiong; Honza, Tatiana; SenGupta, Tanima; Yamani, Naouale El; Murugadoss, Sivakumar; Brochmann, Solveig; Afantitis, Antreas; Dusinska, Maria; Rundén-Pran, Elise; Seif, Johannes P.; Torres, Alejandro Del Real

2024

Poster

DNA damaging effects of occupational exposure to glass fibres. Response to Madl and Keeton paper

Ceppi, Marcello; Smolkova, Bozena; Buocikova, Verona; Rundén-Pran, Elise; Yamani, Naouale El; Longhin, Eleonora Marta; Murugadoss, Sivakumar; Staruchova, Marta; Barancokova, Magdalena; Volkovova, Katarina; Halašová, Erika; Kyrtopoulos, Soterios; Bonassi, Stefano; Collins, Andrew Richard Sherman; Dusinska, Maria

2024

Journal publication

Linking nanomaterial-induced mitochondrial dysfunction to existing adverse outcome pathways for chemicals

Murugadoss, Sivakumar; Vinković Vrček, Ivana; Schaffert, Alexandra; Paparella, Martin; Pem, Barbara; Sosnowska, Anita; Stępnik, Maciej; Martens, Marvin; Willighagen, Egon L.; Puzyn, Tomasz; Cimpan, Mihaela Roxana; Lemaire, Frauke; Mertens, Birgit; Dusinska, Maria; Fessard, Valérie; Hoet, Peter H.

2024

Scientific journal publication

Linking Nanomaterial-Induced Mitochondrial Dysfunction to Existing Adverse Outcome Pathways for Chemicals

Murugadoss, Sivakumar; Vrček, Ivana Vinković; Schaffert, Alexandra; Paparella, Martin; Pem, Barbara; Sosnowska, Anita; Stępnik, Maciej; Martens, Marvin; Willighagen, Egon L.; Puzyn, Tomasz; Cimpan, Mihaela-Roxana; Lemaire, Frauke; Mertens, Birgit; Dusinska, Maria; Fessard, Valérie; Hoet, Peter H.

2023

Scientific journal publication

Towards risk governance of nanomaterials: adaptation and validation of test methods for characterization and hazard assessment

Longhin, Eleonora Marta; Doak, Shareen H.; Lynch, Iseult; Moschini, Elisa; Rundén-Pran, Elise; Yamani, Naouale El; Bouman, Evert; Burgum, Michael J.; Reilly, Katie; Cambier, Sebastien; Gutleb, Arno C.; Cimpan, Mihaela-Roxana; Rios-Mondragon, Ivan; Xue, Ying; Cimpan, Emil; Puzyn, Tomasz; Sosnowska, Anita; Fessard, Valérie; Varet, Julie; Vrček, Ivana Vinković; Pem, Barbara; Fuente, Jesus Martinez de la; Castillo, Victor Manuel Sánchez del; Ayllón, Carlos Cuestas; Hoet, Peter; Murugadoss, Sivakumar; Nunes, Juliana de Souza; Lopez, Aitziber; Dupin, Damien; Ghahremani, MH; Gharailou, D; Badetti, Elena; Brunelli, Andrea; Isigonis, Panagiotis; Afantitis, Antreas; Melagraki, Georgia; Bohmer, Nils; Malsch, Ineke; Dusinska, Maria

2022

Lecture

A strategy towards the generation of testable adverse outcome pathways for nanomaterials

Murugadoss, Sivakumar; Vrcek, Ivana Vinkovic; Pem, Barbara; Jagiello, Karolina; Judzinska, Beata; Sosnowska, Anita; Martens, Marvin; Willighagen, Egon L.; Puzyn, Tomasz; Dusinska, Maria; Cimpan, Mihaela-Roxana; Fessard, Valérie; Hoet, Peter H.

2021

Scientific journal publication

Identifying the relevance of existing adverse outcome pathways for nanomaterials

Murugadoss, Sivakumar; Vrček, Ivana Vinković; Cimpan, Mihaela-Roxana; Pem, Barbara; Martens, Marvin; Willihagen, Egon; Sosnowska, Anita; Puzyn, Tomasz; Dusinska, Maria; Fessard, Valérie; Hoet, Peter

2021

Poster

Development of an Adverse Outcome Pathway for Chronic and Multi-Generational Impacts of Nanomaterials in the Environmental Indicator Species Daphnia Magna

Lynch, Iseult; Reilly, Katie; Cimpan, Mihaela Roxana; Drønen, Anne-Marthe; Rios-Mondragon, Ivan; Cambier, Sébastien; Gutleb, Arno; Serchi, Tommaso; Dusinska, Maria; Rundén-Pran, Elise; Mariussen, Espen; Longhin, Eleonora Marta; Murugadoss, Sivakumar; Hoet, Peter; Willihagen, Egon; Martens, Marvin; Afantitis, Antreas; Melargakis, Georgia; Vrcek, Ivana Vincovik

2020

Lecture

Generation of testable adverse outcome pathways (AOPs) for nanomaterial human hazard assessment

Murugadoss, Sivakumar; Vrcek, Ivana Vincovik; Cimpan, Mihaela-Roxana; Martens, Marvin; Gromelski, Maciej; Puzyn, Tomasz; Fessard, Valérie; Lynch, Iseult; Dusinska, Maria; Hoet, Peter

2020

Lecture

Strengthening the integrated approach of holistic impact assessments for Safe and Sustainable by Design plastic value chain (ANALYST)

ANALYST aims to accelerate the transition towards a safer and more sustainable industrial value chain while encouraging and expanding the existing knowledge on the safe and sustainable by design (SSbD) […]

Project period: 2024 – 2027

Ongoing

Enhanced Safe and Sustainable coatings for supporting the Planet (PROPLANET)

PROPLANET addresses novel coating materials solutions, tackling the problem from a sustainable-business perspective, enabling overcoming the barrier for environmental protection, safety, chemical improvements, and circular value chains. The main goal […]

Project period: 2023 – 2026

Ongoing