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Science-based risk governance of nanotechnology (RiskGone)

Project details

Website: https://riskgone.wp.nilu.no/

Status: Ongoing

Project period: 2019–2023

Principal: EU (814425)

Coordinating institution: NILU

Engineered nanomaterials (ENMs) are covered by REACH/CLP regulations; the general opinion is that the risk assessment (RA) approach routinely used for conventional chemicals is also applicable to ENMs. However, as acknowledged by OECD and ECHA, the OECD and ISO Test Guidelines (TGs) and Standard Operating Procedures (SOPs) need to be verified and adapted to be applicable to ENMs.

Engineered nanomaterials (ENMs) provide the opportunity for breakthroughs in health care, chemical and technology industry. However, ENMs’ unpredictable impact on human health generates increasing concern from the public, academia, and governments worldwide.

ENMs are subject to REACH/CLP regulations. The test procedures need to be verified and adapted for specific use for ENMs (OECD and ISO Test Guidelines (TGs) and Standard Operating Procedures (SOPs)). The national legal frameworks and the international regulations need to be harmonized. RiskGone, a newly financed H2020 project (H2020-NMBP-13-2018 RIA), aims at providing solid procedures for science-based inter-disciplinary risk governance, based on a clear understanding of risks, risk management practices and the societal risk perception by all stakeholders.

Updated: 23.06.2023

Science-based risk governance of nanotechnology has 46 publications at NILU:

Linking nanomaterial-induced mitochondrial dysfunction to existing adverse outcome pathways for chemicals

Murugadoss, Sivakumar; Vinković Vrček, Ivana; Schaffert, Alexandra; Paparella, Martin; Pem, Barbara; Sosnowska, Anita; Stępnik, Maciej; Martens, Marvin; Willighagen, Egon L.; Puzyn, Tomasz; Cimpan, Mihaela Roxana; Lemaire, Frauke; Mertens, Birgit; Dusinska, Maria; Fessard, Valérie; Hoet, Peter H.

2024

Testing ethical impact assessment for nano risk governance

Malsch, Ineke; Isigonis, Panagiotis; Bouman, Evert Alwin; Afantitis, Antreas; Melagraki, Georgia; Dusinska, Maria

2024

Governance of advanced materials: Shaping a safe and sustainable future

Groenewold, Monique; Bleeker, Eric A.J.; Noorlander, Cornelle W.; Sips, Adriënne J.A.M.; van der Zee, Margriet; Aitken, Robert J.; Baker, James H.; Bakker, Martine I.; Bouman, Evert; Doak, Shareen H.; Drobne, Damjana; Dumit, Verónica I.; Florin, Marie-Valentine; Fransman, Wouter; Gonzalez, Mar M.; Heunisch, Elisabeth; Isigonis, Panagiotis; Jeliazkova, Nina; Jensen, Keld Alstrup; Kuhlbusch, Thomas; Lynch, Iseult; Morrison, Mark; Porcari, Andrea; Rodríguez-Llopis, Isabel; Pozuelo, Blanca M.; Resch, Susanne; Säämänen, Arto J.; Serchi, Tommaso; Soeteman-Hernandez, Lya G.; Willighagen, Egon; Dusinska, Maria; Scott-Fordsmand, Janeck J.

2024

Exploring Ethical Impacts of Nanomaterials for Wastewater Remediation

Malsch, Ineke; Isigonis, Panagiotis; Bouman, Evert; Afantitis, Antreas; Melagraki, Georgia; Antunes, Dalila; Dusinska, Maria

2024

A template wizard for the cocreation of machine-readable data-reporting to harmonize the evaluation of (nano)materials

Jeliazkova, Nina; Longhin, Eleonora Marta; El Yamani, Naouale; Rundén-Pran, Elise; Moschini, Elisa; Serchi, Tommaso; Vrček, Ivana Vinković; Burgum, Michael J.; Doak, Shareen H.; Cimpan, Mihaela Roxana; Rios Mondragon, Ivan; Cimpan, Emil; Battistelli, Chiara L.; Bossa, Cecilia; Tsekovska, Rositsa; Drobne, Damjana; Novak, Sara; Repar, Neža; Ammar, Ammar; Nymark, Penny; Di Battista, Veronica; Sosnowska, Anita; Puzyn, Tomasz; Kochev, Nikolay; Iliev, Luchesar; Jeliazkov, Vedrin; Reilly, Katie; Lynch, Iseult; Martine, Bakker; Delpivo, Camilla; Sánchez Jiménez, Araceli; Fonseca, Ana Sofia; Manier, Nicolas; Fernandez-Cruz, María Luisa; Rashid, Shahzad; Willighagen, Egon L.; Apostolova, Margarita D; Dusinska, Maria

2024

Hazard assessment of nanomaterials using in vitro toxicity assays: Guidance on potential assay interferences and mitigating actions to avoid biased results

El Yamani, Naouale; Rundén-Pran, Elise; Varet, Julia; Beus, Maja; Dusinska, Maria; Fessard, Valerie; Moschini, Elisa; Serchi, Tommaso; Cimpan, Mihaela Roxana; Lynch, Iseult; Vinković Vrček, ivana

2024

A portal supporting risk governance of nano- and advanced materials

Fransman, W.; Panagiotis, Isigonis; Afantitis, Antreas; Jensen, Keld Alstrup; Bouman, Evert Alwin; Drobne, D.; Pozuelo Rollón, B.

2023

RISKGONE – Science-based risk governance of nano-technology

Moschini, Elisa; Isigonis, Panagiotis; Bouman, Evert Alwin; Doak, Shareen H.; Longhin, Eleonora Marta; Lynch, Iseult; Malsch, Ineke; Serchi, Tommaso; Steinbach, Christoph; Gutleb, Arno; Dusinska, Maria

2023

Recent Updates in Risk Assessment of Nanomaterials

Dusinska, Maria; Longhin, Eleonora Marta; El Yamani, Naouale; Rundén-Pran, Elise; Elje, Elisabeth; Honza, Tatiana; McFadden, Erin

2023

Genotoxicity assessment of nanomaterials in advanced lung models

Elje, Elisabeth; Mariussen, Espen; McFadden, Erin; Camassa, Laura Maria Azzurra; Dusinska, Maria; Zienolddiny, Shanbeh; Rundén-Pran, Elise

2023

New approaches to hazard and risk assessment of nanomaterials. RiskGONE perspective.

Dusinska, Maria; Longhin, Eleonora Marta; El Yamani, Naouale; Rundén-Pran, Elise; Elje, Elisabeth

2023

Linking Nanomaterial-Induced Mitochondrial Dysfunction to Existing Adverse Outcome Pathways for Chemicals

Murugadoss, Sivakumar; Vrček, Ivana Vinković; Schaffert, Alexandra; Paparella, Martin; Pem, Barbara; Sosnowska, Anita; Stępnik, Maciej; Martens, Marvin; Willighagen, Egon L.; Puzyn, Tomasz; Cimpan, Mihaela-Roxana; Lemaire, Frauke; Mertens, Birgit; Dusinska, Maria; Fessard, Valérie; Hoet, Peter H.

2023

Current status and future challenges of genotoxicity OECD Test Guidelines for nanomaterials: a workshop report

Doak, Shareen H.; Andreoli, Cristina; Burgum, Michael J.; Chaudhry, Qasim; Bleeker, Eric; Bossa, Cecilia; Domenech, Josefa; Drobne, Damjana; Fessard, Valérie; Jeliazkova, Nina; Longhin, Eleonora Marta; Rundén-Pran, Elise; Stepnik, Maciej; El Yamani, Naouale; Catalán, Julia; Dusinska, Maria

2023

Rapid identification of in vitro cell toxicity using an electrochemical membrane screening platform

Kohl, Yvonne; William, Nicola; Elje, Elisabeth; Backes, Nadine; Rothbauer, Mario; Srancikova, Annamaria; Rundén-Pran, Elise; El Yamani, Naouale; Korenstein, Rafi; Madi, Lea; Barbul, Alexander; Kozics, Katarina; Sramkova, Monika; Steenson, Karen; Gabelova, Alena; Ertl, Peter; Dusinska, Maria; Nelson, Andrew

2023

50 Human Hazard Assessment of Nanomaterials: Supporting Risk Decision Making Through Interlaboratory Trial Data

Burgum, Michael J.; El Yamani, Naouale; Longhin, Eleonora Marta; Mariussen, Espen; Rundén-Pran, Elise; Sosnowska, Anita; Puzyn, Tomasz; Clift, Martin J. D.; Dusinska, Maria; Doak, Shareen H.

2023

An In Vitro Dosimetry Tool for the Numerical Transport Modeling of Engineered Nanomaterials Powered by the Enalos RiskGONE Cloud Platform

Cheimarios, Nikolaos; Pem, Barbara; Tsoumanis, Andreas; Ilic, Krunoslav; Vrček, Ivana Vinković; Melagraki, Georgia; Bitounis, Dimitrios; Isigonis, Panagiotis; Dusinska, Maria; Lynch, Iseult; Demokritou, Philip; Afantitis, Antreas

2022

The miniaturized enzyme-modified comet assay for genotoxicity testing of nanomaterials

El Yamani, Naouale; Rundén-Pran, Elise; Collins, Andrew Richard; Longhin, Eleonora Marta; Elje, Elisabeth; Hoet, Peter; Vrček, Ivana Vinković; Doak, Shareen H.; Fessard, Valérie; Dusinska, Maria

2022

The alamar blue assay in the context of safety testing of nanomaterials

Longhin, Eleonora Marta; El Yamani, Naouale; Rundén-Pran, Elise; Dusinska, Maria

2022

A Portal and IT infrastructure supporting Risk Governance of nano- and advanced materials and nano-enabled products

Bouman, Evert Alwin; Isigonis, Panagiotis; Afantitis, Antreas; Jensen, K. A.; Fransman, W.; Porcari, A.; Drobne, D.; Suarez-Merino, B.; Hristozov, D.; Pozuelo Rollón, B.; Ballesteros, A.; Rodriguez-Llopis, I.; Säämänen, A.; Bakker, M.

2022

Towards risk governance of nanomaterials: adaptation and validation of test methods for characterization and hazard assessment

Longhin, Eleonora Marta; Doak, Shareen H.; Lynch, Iseult; Moschini, Elisa; Rundén-Pran, Elise; El Yamani, Naouale; Bouman, Evert; Burgum, Michael J.; Reilly, Katie; Cambier, Sebastien; Gutleb, Arno C.; Cimpan, Mihaela-Roxana; Rios-Mondragon, Ivan; Xue, Ying; Cimpan, Emil; Puzyn, Tomasz; Sosnowska, Anita; Fessard, Valérie; Varet, Julie; Vinković Vrček, Ivana; Pem, Barbara; de la Fuente, Jesus Martinez; Sánchez del Castillo, Victor Manuel; Cuestas Ayllón, Carlos; Hoet, Peter; Murugadoss, Sivakumar; de Souza Nunes, Juliana; Lopez, Aitziber; Dupin, Damien; Ghahremani, MH; Gharailou, D; Badetti, Elena; Brunelli, Andrea; Isigonis, Panagiotis; Afantitis, Antreas; Melagraki, Georgia; Bohmer, Nils; Malsch, Ineke; Dusinska, Maria

2022

Genotoxicity assessment of lung cells cultured at the air-liquid interface: comparison of bronchial and alveolar mono- and cocultures

Elje, Elisabeth; McFadden, Erin; Mariussen, Espen; Dusinska, Maria; Rundén-Pran, Elise

2022

Validation of an advanced 3D respiratory tri-culture model at the air-liquid interface for hazard assessment of nanomaterials

Camassa, Laura Maria Azzurra; Elje, Elisabeth; Mariussen, Espen; Longhin, Eleonora Marta; Haugen, Kristine; Dusinska, Maria; Zienolddiny-Narui, Shan; Rundén-Pran, Elise

2022

The colony forming efficiency assay for toxicity testing of nanomaterials—Modifications for higher-throughput

Rundén-Pran, Elise; Mariussen, Espen; El Yamani, Naouale; Elje, Elisabeth; Longhin, Eleonora Marta; Dusinska, Maria

2022

Lack of mutagenicity of TiO2 nanoparticles in vitro despite cellular and nuclear uptake

El Yamani, Naouale; Rubio, Laura; García-Rodríguez, Alba; Kažimírová, Alena; Rundén-Pran, Elise; Barančoková, Magdaléna; Marcos, Ricard; Dusinska, Maria

2022

European Registry of Materials: global, unique identifiers for (undisclosed) nanomaterials

van Rijn, Jeaphianne; Afantitis, Antreas; Culha, Mustafa; Dusinska, Maria; Exner, Thomas E.; Jeliazkova, Nina; Longhin, Eleonora Marta; Lynch, Iseult; Melagraki, Georgia; Nymark, Penny; Papadiamantis, Anastasios; Winkler, David A.; Yilmaz, Hulya; Willighagen, Egon

2022

Hazard identification of nanomaterials: In silico unraveling of descriptors for cytotoxicity and genotoxicity

El Yamani, Naouale; Mariussen, Espen; Gromelski, Maciej; Wyrzykowska, Ewelina; Grabarek, Dawid; Puzyn, Tomasz; Tanasescu, Speranta; Dusinska, Maria; Rundén-Pran, Elise

2022

Do cytotoxicity and cell death cause false positive results in the in vitro comet assay?

Azqueta, Amaya ; Stopper, Helga; Zegura, Bojana; Dusinska, Maria; Møller, Peter

2022

Do Carbon Nanotubes and Asbestos Fibers Exhibit Common Toxicity Mechanisms?

Gupta, Suchi Smita; Singh, Krishna P.; Gupta, Shailendra; Dusinska, Maria; Rahman, Qamar

2022

Standardisation of mutagenicity testing approaches, tailored to the evaluation of engineered nanomaterials

Burgum, Michael J.; El Yamani, Naouale; Sosnowska, Anita; Stolinski, Filip; Longhin, Eleonora Marta; Mariussen, Espen; Rundén-Pran, Elise; Jenkins, Gareth; Clift, Martin J. D.; Puzyn, Tomasz; Dusinska, Maria; Doak, Shareen H.

2021

Identifying the relevance of existing adverse outcome pathways for nanomaterials

Murugadoss, Sivakumar; Vrček, Ivana Vinković; Cimpan, Mihaela-Roxana; Pem, Barbara; Martens, Marvin; Willihagen, Egon; Sosnowska, Anita; Puzyn, Tomasz; Dusinska, Maria; Fessard, Valérie; Hoet, Peter

2021

A strategy towards the generation of testable adverse outcome pathways for nanomaterials

Murugadoss, Sivakumar; Vrcek, Ivana Vinkovic; Pem, Barbara; Jagiello, Karolina; Judzinska, Beata; Sosnowska, Anita; Martens, Marvin; Willighagen, Egon L.; Puzyn, Tomasz; Dusinska, Maria; Cimpan, Mihaela-Roxana; Fessard, Valérie; Hoet, Peter H.

2021

Towards FAIR nanosafety data

Jeliazkova, Nina; Apostolova, Margarita D.; Andreoli, Cristina; Barone, Flavia; Barrick, Andrew; Battistelli, Chiara L.; Bossa, Cecilia; Botea-Petcu, Alina; Chatel, Amelie; De Angelis, Isabella; Dusinska, Maria; El Yamani, Naouale; Gheorghe, Daniela; Giusti, Anna; Gómez-Fernández, Paloma; Grafström, Roland; Gromelski, Maciej; Jacobsen, Nicklas Raun; Jeliazkov, Vedrin; Jensen, Keld Alstrup; Kochev, Nikolay; Kohonen, Pekka; Manier, Nicolas; Mariussen, Espen; Mech, Agnieszka; Navas, José María; Paskaleva, Vesselina; Precupas, Aurica; Puzyn, Tomasz; Rasmussen, Kirsten; Ritchie, Peter; Llopis, Isabel Rodriguez; Rundén-Pran, Elise; Sandu, Romica; Shandilya, Neeraj; Tanasescu, Sperenta; Haase, Andrea; Nymark, Penny

2021

Editorial for the Special Issue From Nanoinformatics to Nanomaterials Risk Assessment and Governance

Lynch, Iseult; Afantitis, Antreas; Greco, Dario; Dusinska, Maria; Banares, Miguel A.; Melagraki, Georgia

2021

Reflecting on Ethics of Nanosafety

Malsch, Ineke; Panagiotis, Isigonis; Bouman, Evert; Afantitis, Antreas; Melagraki, Georgia; Lynch, Iseult; Cimpan, Mihaela-Roxana; Dusinska, Maria

2020

Screening Nano-Ethical Issues

Malsch, Ineke; Isigonis, Panagiotis; Bouman, Evert; Afantitis, Antreas; Melagraki, Georgia; Lynch, Iseult; Cimpan, Mihaela-Roxana; Dusinska, Maria

2020

Reflecting on Ethical, Legal and Societal Aspects of Nanosafety

Malsch, Ineke; Panagiotis, Isigonis; Bouman, Evert; Afantitis, Antreas; Melagraki, Georgia; Lynch, Iseult; Cimpan, Mihaela-Roxana; Dusinska, Maria

2020

Generation of testable adverse outcome pathways (AOPs) for nanomaterial human hazard assessment

Murugadoss, Sivakumar; Vincovik Vrcek, Ivana; Cimpan, Mihaela-Roxana; Martens, Marvin; Gromelski, Maciej; Puzyn, Tomasz; Fessard, Valérie; Lynch, Iseult; Dusinska, Maria; Hoet, Peter

2020

Development of an Adverse Outcome Pathway for Chronic and Multi-Generational Impacts of Nanomaterials in the Environmental Indicator Species Daphnia Magna

Lynch, Iseult; Reilly, Katie; Cimpan, Mihaela Roxana; Drønen, Anne-Marthe; Rios-Mondragon, Ivan; Cambier, Sébastien; Gutleb, Arno; Serchi, Tommaso; Dusinska, Maria; Rundén-Pran, Elise; Mariussen, Espen; Longhin, Eleonora Marta; Murugadoss, Sivakumar; Hoet, Peter; Willihagen, Egon; Martens, Marvin; Afantitis, Antreas; Melargakis, Georgia; Vincovik Vrcek, Ivana

2020

Genotoxicity of nanomaterials: Advanced in vitro models and high throughput methods for human hazard assessment—a review

Kohl, Yvonne; Rundén-Pran, Elise; Mariussen, Espen; Hesler, Michelle; El Yamani, Naouale; Longhin, Eleonora Marte; Dusinska, Maria

2020

Risk governance of emerging technologies demonstrated in terms of its applicability to nanomaterials

Isigonis, Panagiotis; Afantitis, Antreas; Antunes, Dalila; Bartonova, Alena; Beitollahi, Ali; Bohmer, Nils; Bouman, Evert; Chaudhry, Qasim; Cimpan, Mihaela Roxana; Cimpan, Emil; Doak, Shareen; Dupin, Damien; Fredrigo, Doreen; Fessard, Valérie; Gromelski, Maciej; Gutleb, Arno C.; Halappanavar, Sabina; Hoet, Peter; Jeliazkova, Nina; Jomini, Stephane; Lindner, Sabine; Linkov, Igor; Longhin, Eleonora Marte; Lynch, Iseult; Malsch, Ineke; Marcomini, Antonio; Mariussen, Espen; de la Fuente, Jesus M.; Melagraki, Georgia; Murphy, Finbarr; Neaves, Michael; Packroff, Rolf; Pfuhler, Stefan; Puzyn, Tomasz; Rahman, Qamar; Rundén-Pran, Elise; Semenzin, Elena; Serchi, Tommaso; Steinbach, Christoph; Trump, Benjamin; Vrcek, Ivana Vinkovic; Warheit, David; Wiesner, Mark R,; Willighagen, Egon; Dusinska, Maria

2020

Embedding Ethical Impact Assessment in Nanosafety Decision Support

Malsch, Ineke; Isigonis, Panagiotis; Dusinska, Maria; Bouman, Evert

2020

Thermodynamic parameters at bio-nano interface and nanomaterial toxicity: A case study on BSA interaction with ZnO, SiO2 and TiO2

Precupas, Aurica; Gheorghe, Daniela; Botea-Petcu, Alina; Leonties, Anca Ruxandra; Sandu, Romica; Popa, Vlad Tudor; Mariussen, Espen; El Yamani, Naouale; Rundén-Pran, Elise; Dumit, Veronica; Xue, Ying; Cimpan, Mihaela Roxana; Dusinska, Maria; Haase, Andrea; Tanasescu, Speranta

2020

Hepato(Geno)Toxicity Assessment of Nanoparticles in a HepG2 Liver Spheroid Model

Elje, Elisabeth; Mariussen, Espen; Moriones, Oscar H.; Bastus, Neus G.; Puntes, Victor; Kohl, Yvonne; Dusinska, Maria; Rundén-Pran, Elise

2020

Effects of titanium dioxide nanoparticles on the Hprt gene mutations in V79 hamster cells

Kazimirova, Alena; El Yamani, Naouale; Rubio, Laura; Garcia-Rodriguez, Alba; Barancokova, Magdalena; Marcos, Ricard; Dusinska, Maria

2020