Found 9849 publications. Showing page 286 of 394:
DNA double‐strand breaks in Arctic char (Salvelinus alpinus) from Bjørnøya in the Norwegian Arctic
High levels of organochlorine contaminants (OCs) have been found in arctic char (Salvelinus alpinus) from Lake Ellasjøen, Bjørnøya (Norwegian Arctic). The aim of the present study was to investigate the potential genotoxic effect of environmental organochlorine contaminant exposure in arctic char from Ellasjøen compared with arctic char from the low‐contaminated Lake Laksvatn nearby. Blood was analyzed using agarose gel electrophoresis and image data analysis to quantify the fraction of total DNA that migrated into the gel (DNA‐FTM) as a relative measure of DNA double‐strand breaks (DSBs). Analysis by GC‐MS of muscle samples showed an average 43 times higher concentration of ΣOCs in arctic char from Ellasjøen (n = 18) compared with Laksvatn char (n = 21). Char from Lake Ellasjøen had a much higher frequency of DSBs, as measured by DNA‐FTM, than char from Lake Laksvatn. Principal component analysis and multiple linear regressions show that there was a significant positive relationship between DSBs and levels of organochlorine contaminants in the char. In addition, DSBs were less frequent in reproductively mature char than in immature char. The results suggest that organochlorine contaminants are genotoxic to arctic char.
Pergamon Press
2019
2014
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2024
2021
2018
Environmental contaminants are found throughout Arctic marine ecosystems, and their presence in seabirds has been
associated with toxicological responses. However, there are few studies of genotoxicity in Arctic avian wildlife. The purpose of
the present study was to quantify deoxyribonucleic acid (DNA) damage in lymphocytes of selected seabird species and to
examine whether accumulation of organohalogen contaminants (SOHCs) affects DNA damage. Blood was sampled from
common eider (Somateria mollissima), black guillemot (Cepphus grylle), black-legged kittiwake (Rissa tridactyla), glaucous gull
(Larus hyperboreus), arctic skua (Stercorarius parasiticus), and great skua (Stercorarius skua) in Kongsfjorden, Svalbard (Norway).
Contaminant concentrations found in the 6 species differed, presumably because of foraging ecology and biomagnification.
Despite large differences in contaminant concentrations, ranging from SOHCs 3.3 ng/g wet weight in the common eider to
SOHCs 895 ng/g wet weight in the great skua, there was no strong difference among the species in baseline DNA damage or
sensitivity to a genotoxic stressor (hydrogen peroxide). Baseline levels of DNA damage were low, with median values ranging
from 1.7% in the common eider to 8.6% in the great skua. There were no associations between DNA damage and contaminants
in the investigated species, suggesting that contaminant concentrations in Kongsfjorden are too low to evoke genotoxic effects,
or possibly that lymphocytes are resistant to strand breakage. Clearly, genotoxicity is a topic for future studies of Arctic seabirds
Arctic; Seabirds; Genotoxicity; Comet Assay; Persistent organic pollutants; Perfluoroalkyl substances
Pergamon Press
2018
2016
2010
2012
2010
2019
2009
Distribution of polychlorinated biphenyls (PCBs) in snow samples in northern Norway. Organohalogen compounds, 39
1998
1999
2016
2012
2012
2023
Oxford University Press
2019
2016
2017
Disse miljøgiftene fant forskerne igjen i de ville dyrene
Norges forskningsråd
2024
2000