Found 10000 publications. Showing page 338 of 400:
Citi-Sense-MOB. Conceptual services design document. NILU OR
This report gives an overview of the service system design, requirements, specifications and architecture for the main products ¿ Citi-Sense-MOB Citizen Observatory Toolbox (COT), which comprises of a series of applications that support and complement each other. These include the concept for COT, service design concept and methodologies, the COT target groups, and a set of COT (e.g., data, web apps, mobile apps, maps, services, methodologies, etc.).
2014
2012
2012
Citi-Sense MOB. Provisioning of social media platform. NILU OR
This report presents various social media platforms that have been created to foster communication between the Citi-Sense-MOB project¿s partners, stakeholders and users, and to facilitate citizens¿ engagement, participation and network building. It contains Citizens¿ Observatories Facebook Page, Oslo Citizens¿ Observatory Facebook Page, Citizens¿ Observatories Twitter Account, Citi-Sense-MOB Twitter Account, Citizens¿ Observatories LinkedIn Group, Citi-Sense-MOB Online Forum and Blogs, Citi-Sense-MOB App.
2014
CITI-SENSE Citizens' Observatories Architecture
This paper introduces the architecture of the CITI-SENSE Citizens’ Observatories based on the ISO 19119 reference model. It describes the various parts of the architecture including boundary services with sensors and apps and data management services with the CITI-SENSE data model. It also describes the Web Feature Service (WFS) storage support and the reusable visualisation widgets used for both apps and web portals in various Citizens’ Observatories.
2018
2016
2013
2007
2002
2003
Circulating MicroRNAs in Cord Blood to Predict Attention-Deficit/Hyperactivity Disorder Diagnosis
Background
There are large knowledge gaps in the etiology of attention-deficit/hyperactivity disorder (ADHD), and although it is a prevalent and highly heritable neurodevelopmental disorder, diagnosis can be challenging. We aimed to assess the association of circulating blood plasma microRNAs (miRNAs) at birth with ADHD for use as biomarker candidates and build an miRNA-based prediction model.
Methods
Our study population consisted of 206 children with ADHD (33.0% female), 207 control children (33.8% female), and their parents from the MoBa (Norwegian Mother, Father, and Child Cohort Study). Expression levels of 51 selected miRNAs in plasma from children’s cord blood at birth and from both parents during early pregnancy were quantified by quantitative polymerase chain reaction and tested for association with children’s ADHD diagnosis and ADHD symptom scores based on ratings by parents.
Results
Seven miRNAs were differentially expressed at birth in children with ADHD and control children (false discovery rate < .05), and 31 had a statistically significant linear relationship with parent-rated ADHD symptom score at 8 years. A 19-miRNA ADHD prediction model achieved good discrimination in the test population (area under the receiver operating curve = 0.959, accuracy = 0.893). Functional analysis for the 19-miRNA prediction set revealed involvement in several highly relevant pathways, e.g., dopaminergic synapse, circadian rhythm, and axon guidance. We also found that parental miRNA expression levels significantly associated with children’s ADHD diagnoses and/or ADHD symptoms scores.
Conclusions
We showed that expression levels of circulating miRNAs at birth may be used to predict increased risk of ADHD diagnosis, and our 19-miRNA set should be included in future efforts to develop a biomarker panel.
2025