Found 9764 publications. Showing page 347 of 391:
Rapporten gir en oversikt over Norges luftkvalitetsmålenettverk. Alle målestasjoner som rapporterer måledata til EEA/ESA er beskrevet og plasseringen er vurdert i forhold til krav i EUs direktiver.
Omgivelsene til stasjonene er beskrevet og viktige kilder til utslipp er identifisert. Plasseringen av målestasjonene er dokumentert med kart og flybilde og retningsvisende fotografier av området.
Avvik fra plasseringskriteriene er dokumentert. Anbefalinger for justeringer er gitt for enkelte stasjoner.
NILU
2022
Acquired drug resistance and metastasis in breast cancer (BC) are coupled with epigenetic deregulation of gene expression. Epigenetic drugs, aiming to reverse these aberrant transcriptional patterns and sensitize cancer cells to other therapies, provide a new treatment strategy for drug-resistant tumors. Here we investigated the ability of DNA methyltransferase (DNMT) inhibitor decitabine (DAC) to increase the sensitivity of BC cells to anthracycline antibiotic doxorubicin (DOX). Three cell lines representing different molecular BC subtypes, JIMT-1, MDA-MB-231 and T-47D, were used to evaluate the synergy of sequential DAC + DOX treatment in vitro. The cytotoxicity, genotoxicity, apoptosis, and migration capacity were tested in 2D and 3D cultures. Moreover, genome-wide DNA methylation and transcriptomic analyses were employed to understand the differences underlying DAC responsiveness. The ability of DAC to sensitize trastuzumab-resistant HER2-positive JIMT-1 cells to DOX was examined in vivo in an orthotopic xenograft mouse model. DAC and DOX synergistic effect was identified in all tested cell lines, with JIMT-1 cells being most sensitive to DAC. Based on the whole-genome data, we assume that the aggressive behavior of JIMT-1 cells can be related to the enrichment of epithelial-to-mesenchymal transition and stemness-associated pathways in this cell line. The four-week DAC + DOX sequential administration significantly reduced the tumor growth, DNMT1 expression, and global DNA methylation in xenograft tissues. The efficacy of combination therapy was comparable to effect of pegylated liposomal DOX, used exclusively for the treatment of metastatic BC. This work demonstrates the potential of epigenetic drugs to modulate cancer cells' sensitivity to other forms of anticancer therapy.
Elsevier
2022
Content and migration of chemical additives from plastic products
NILU has, on behalf of the Norwegian Environment Agency, performed chemical analyses of a selection of additives in plastic products. The goal was to identify content and migration of the chemical additives in and from the products to air and surfaces of the products at room temperature. The plastic products covered extension cord, sockets, flooring, wall papers, upholstery, PC-mouse and PCs. Targeted chemicals were organophosphorous flame retardants (OPFRs), brominated flame retardants (BFRs) including TBBPA, and chlorinated substances. TPHP (triphenyl phosphate) was detected in most sample types, but the highest concentrations were found for TBEP (tris(2-butoxyethyl)phosphate. The highest number of compounds were detected in the PC-mouses and high levels were also found in the surface wipes on PC-mouses. None of the targeted compounds were detected in the air samples.
NILU
2022
2022
Grenseområdene Norge-Russland. Luft- og nedbørkvalitet 2021.
Smelteverkene i nordvest-Russland slapp tidligere ut store mengder svoveldioksid (SO2) og tungmetaller. Utslippene påvirket luft- og nedbørkvalitet i grenseområdene. Smelteverket i Nikel stengte ned 23. desember 2020 og lokal luftkvalitet ble betydelig forbedret. Dog er det fortsatt utslipp fra varmekraftverket i Nikel i den kalde årstiden. Detaljer rundt utslippene fra Zapoljarnyj er ikke kjente. Herværende rapport viser resultatene for kalenderåret 2021, det vil si året etter stengningen. Nivåene av forurensning er lave og grenseverdier og målsettingsverdier er overholdt med klar margin.
NILU
2022
2022
Robust evidence for reversal of the trend in aerosol effective climate forcing
Anthropogenic aerosols exert a cooling influence that offsets part of the greenhouse gas warming. Due to their short tropospheric lifetime of only several days, the aerosol forcing responds quickly to emissions. Here, we present and discuss the evolution of the aerosol forcing since 2000. There are multiple lines of evidence that allow us to robustly conclude that the anthropogenic aerosol effective radiative forcing (ERF) – both aerosol–radiation interactions (ERFari) and aerosol–cloud interactions (ERFaci) – has become less negative globally, i.e. the trend in aerosol effective radiative forcing changed sign from negative to positive. Bottom-up inventories show that anthropogenic primary aerosol and aerosol precursor emissions declined in most regions of the world; observations related to aerosol burden show declining trends, in particular of the fine-mode particles that make up most of the anthropogenic aerosols; satellite retrievals of cloud droplet numbers show trends in regions with aerosol declines that are consistent with these in sign, as do observations of top-of-atmosphere radiation. Climate model results, including a revised set that is constrained by observations of the ocean heat content evolution show a consistent sign and magnitude for a positive forcing relative to the year 2000 due to reduced aerosol effects. This reduction leads to an acceleration of the forcing of climate change, i.e. an increase in forcing by 0.1 to 0.3 W m−2, up to 12 % of the total climate forcing in 2019 compared to 1750 according to the Intergovernmental Panel on Climate Change (IPCC).
2022
2022
2022
The EmSite model for high resolution emissions from machinery in construction sites
The report describes the EmSite model developed to estimate exhaust and non-exhaust emissions from non-road mobile machinery (NRMM) used in building and construction. The model is based on a complete national database of the exact location of construction and building activity, machine registries and variables that affect emissions (ground conditions, meteorology, type of ground material). EmSite model allows us to determine, i) the location, area and time of construction projects at fine resolution; ii) energy demand for NRMM; and iii) fuel consumption, air pollutants and GHGs emissions. For exhaust emissions, specific dynamic emission factors for NRMMs were developed. For non-exhaust emissions, an approach based on the Tier 1 (EMEP/EEA Guidebook, 2019) was chosen. EmSite allows for bottom-up estimates for NRMM employed in construction, and the results are comparable with official air pollutant and GHGs emissions.
NILU
2022
A pooled analysis of molecular epidemiological studies on modulation of DNA repair by host factors
Levels of DNA damage represent the dynamics between damage formation and removal. Therefore, to better interpret human biomonitoring studies with DNA damage endpoints, an individual’s ability to recognize and properly remove DNA damage should be characterized. Relatively few studies have included DNA repair as a biomarker and therefore, assembling and analyzing a pooled database of studies with data on base excision repair (BER) was one of the goals of hCOMET (EU-COST CA15132). A group of approximately 1911 individuals, was gathered from 8 laboratories which run population studies with the comet-based in vitro DNA repair assay. BER incision activity data were normalized and subsequently correlated with various host factors. BER was found to be significantly higher in women. Although it is generally accepted that age is inversely related to DNA repair, no overall effect of age was found, but sex differences were most pronounced in the oldest quartile (>61 years). No effect of smoking or occupational exposures was found. A body mass index (BMI) above 25 kg/m2 was related to higher levels of BER. However, when BMI exceeded 35 kg/m2, repair incision activity was significantly lower. Finally, higher BER incision activity was related to lower levels of DNA damage detected by the comet assay in combination with formamidopyrimidine DNA glycosylase (Fpg), which is in line with the fact that oxidatively damaged DNA is repaired by BER. These data indicate that BER plays a role in modulating the steady-state level of DNA damage that is detected in molecular epidemiological studies and should therefore be considered as a parallel endpoint in future studies.
2022
2022
Emission inventories indicate that thallium, a highly toxic metal, is emitted during coal burning and cement production. These estimates have been established only for the 1980s and 1990s but up to now they have not been compared to long-term observations. Here we used alpine ice cores to document thallium pollution over Europe since ∼1850. Ice-core thallium concentrations increased from 1890 to 1910, and decreased after 1965 to concentrations that were half 1890 levels. Comparison of ice-core trends, estimated past emissions, and state-of-the-art atmospheric aerosol transport modeling suggest that coal burning was responsible for thallium pollution in Europe, particularly from 1920 to 1965 because of high coal consumption at that time. The subsequent decline resulted from decreased coal consumption and reduced emissions following technological improvements. The ice-core data suggest that the rapid growth of cement production that took place in Europe after 1950 had a limited impact on thallium pollution.
American Geophysical Union (AGU)
2022
2022
2022