Found 10360 publications. Showing page 401 of 415:
2025
2025
Best Practice Protocol for the validation of Aerosol, Cloud, and Precipitation Profiles (ACPPV)
Committee on Earth Observation Satellites - CEOS
2025
Introduction
Per- and polyfluoroalkyl substances (PFAS) have been linked to effects on human lipid profiles, with several epidemiological studies reporting associations between specific PFAS and blood lipid concentrations. However, these associations have been inconsistent, and most studies have focused on cross-sectional analyses with limited repeated measurements.
Objective
In this study, we investigated associations between serum PFAS concentrations and major blood lipid classes over a 30-year period (1986–2016) and up to five time points. Lipids analyzed included total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), and triglycerides (TG).
Methods
This study included 145 participants from The Tromsø Study, Norway, who donated plasma samples three to five times over the study period. Linear mixed-effects (LME) models assessed longitudinal associations between PFAS and lipid classes, while multiple linear regression (MLR) models were used for cross-sectional associations.
Results
LME models demonstrated positive longitudinal associations between perfluorooctanoic acid (PFOA), perfluorononanoic acid (PFNA), perfluorodecanoic acid (PFDA), perfluoroundecanoic acid (PFUnDA), perfluorododecanoic acid (PFDoDA), and perfluorotridecanoic acid (PFTrDA) with TC. Additionally, PFOA, PFDA, PFUnDA, PFDoDA, and PFTrDA were associated with LDL-C, and PFUnDA and summed perfluorooctane sulfonate isomers (∑PFOS) with HDL-C. Cross-sectional analyses corroborated positive associations between the six PFAS compounds and TC at least three times, but the LDL-C and HDL-C associations were not confirmed. Summed perfluorooctane sulfonamide isomers (∑PFOSA) showed a negative association with LDL-C longitudinally, but this was not confirmed cross-sectionally. No associations were observed between PFAS and TG, longitudinally or cross-sectionally.
Conclusion
Concentrations of multiple PFAS were positively associated with blood lipids in longitudinal analyses, with the most consistent associations observed between six PFCA compounds and TC. These findings highlight the need for further investigation into these complex associations.
2025
Sex and Gender Dimensions in Hazard and Risk Assessment of Engineered Nanomaterials
The knowledge on hazards and risks connected to human exposure to engineered nanomaterials (ENMs) is still very limited, despite several decades of research and regulatory efforts at the international level. In particular, sex/gender‐related responses to such exposure have not been clearly articulated so far in any of the existing guidance documents or regulatory relevant opinions provided to the parties involved in the risk assessment and risk management of ENMs. We aimed to demonstrate the relevance of the sex/gender dimension for the characterization of the risks and hazards associated with ENMs by analyzing existing scientific data on sex‐related differences in response to ENMs exposure. This was achieved by performing an extensive review of in vivo mammalian toxicity studies published in PubMed and Web of Science databases. Further analysis was performed only for data reported in publications that satisfied scientific quality criteria assessed using the GUIDEnano approach. Finally, we demonstrated the importance of the sex/gender dimension for safety testing of ENMs in the future and provided recommendations on how to include the sex/gender dimension in toxicity testing of ENMs to ensure precise, transparent, and reliable conclusions in the process of hazard and risk assessments. This article is categorized under: Toxicology and Regulatory Issues in Nanomedicine > Toxicology of Nanomaterials Toxicology and Regulatory Issues in Nanomedicine > Regulatory and Policy Issues in Nanomedicine
2025
Melkøya ferskvann, nedbør, vegetasjon og jord 2024
I 2024 var det igjen tid for den tradisjonelle overvåkningen av ferskvann. I forbindelse med endringer i produksjonen og mulige økte utslipp av kvikksølv ble det gjort enkelte endringer i programmet for ferskvann samtidig som det ble iverksatt undersøkelser av kvikksølv (Hg), bly (Pb) og polysykliske aromatiske hydrokarboner (PAH) i nedbør, vegetasjon og jord. I det nye programmet er det god samlokalisering mellom prøvetakingsstasjoner for ferskvann, nedbør, vegetasjon og jordprøver.
Det ble gjennomført innsamling av prøver i ferskvann, nedbør, vegetasjon og jord fra starten av september.
Akvaplan-niva
2025
State of the Climate in 2024: Global Climate
For the second year in a row, record-high global surface temperatures were set in 2024, according to all six global temperature datasets assessed in this report (Berkeley Earth, GISTEMP, HadCRUT5, the NOAA Merged Land Ocean Global Surface Temperature Analysis [NOAAGlobalTemp], ERA5, and the Japanese Reanalysis for Three Quarters of a Century [JRA-3Q]). The last time consecutive years set records was in 2015 and 2016 when a strong El Niño similarly boosted global temperatures. The last 10 years (2015–24) are now the warmest 10 in the instrumental record—warmer than the 2011–20 average—and hence “more likely than not warmer than any multi-century period after the last interglacial period, roughly 125,000 years ago” (Gulev et al. 2021). The increased energy within the climate system is detectable at the top of the atmosphere, with the outgoing longwave radiation anomaly continuing to be above the range of natural variability.
During 2024, El Niño conditions that had been present since the middle of 2023 faded to neutral by the end of the year. The warm conditions observed around the globe over the last two years had impacts across the climate system, as demonstrated by many of the metrics presented in this chapter. Other temperature metrics also reached record levels over the instrumental periods assessed in this chapter: over the oceans at night, on the surfaces of lakes, and in the lower troposphere as well as measures of equivalent temperature (which considers the moisture contribution to heat), and high and low temperature extremes.
The frozen parts of Earth responded with permafrost temperatures continuing to reach record-high levels in many locations, and the active-layer thickness (the portion that melts and refreezes annually) also increasing at most sites. Repeated high temperatures over the European Alps during recent summers has led to large increases in rock glacier velocities in that region. The Great Lakes had much-below-average ice cover over the 2023/24 winter, and there was below-average snow cover extent in the Northern Hemisphere. All 58 reference glaciers across five continents lost ice during 2024, resulting in the greatest average ice loss in the record, which began in 1970. One more glacier was also declared extinct during 2024.
Higher global temperatures impacted the water cycle. Although lower than 2023 values, water evaporation from land in the Northern Hemisphere reached one of the highest annual values on record, in line with the long-term increasing trend. Specific humidity reached record levels over land and ocean, and relative humidity over both domains was higher than 2023. There was little relief from high humid-heat conditions, with the frequency of high humid-heat days at a record level and intensity at the second-highest level in the record—only a fraction of a degree cooler than that of 2023. The global atmosphere contained the greatest amount of water vapor in the record, and over one-fifth of the globe recorded their highest values. This far exceeded 2023, where only one-tenth of the globe experienced record-high total column water vapor. Rainfall was globally high; 2024 was the third-wettest year since records began in 1983. However, rainfall over land was close to average, while over the ocean it was the fourth-wettest year on record (following 2015, 2016, and 1998). Extreme rainfall, as characterized by the annual maximum daily rainfall over land, was the wettest on record. Averaged globally (4190 lakes), lakes had a small increase in water storage, and regionally, over 40% of monitored lakes showed significant changes in storage and level.
The effects of ongoing droughts in southern Africa and in North and South America can be seen in the soil moisture and water storage patterns. They are also apparent in the river discharge and runoff levels, which are topics that will be covered in the chapter after a few years of absence. Globally, however, drought severity and extent decreased from the record set in 2023.
Atmospheric concentrations of the three main greenhouse gases (carbon dioxide [CO2], methane [CH4], nitrous oxide [N2O]) again all reached record levels, with a record-equal annual increase in the annual change of CO2 concentrations. However, concentrations of ozone-depleting substances continued to decline, corroborated by stratospheric ozone columns well above the 1998–2008 average, especially in the Northern Hemisphere. In contrast, stratospheric aerosols remained high because of the Ruang eruption in April 2024, affecting the atmospheric transmission of solar radiation over Hawaii later in the year, and the ongoing effects from the Hunga eruption in 2022. The latter eruption also caused the ongoing elevated stratospheric water vapor concentrations.
Our planet’s surface albedo continued to darken with increased plant growth and decreased snow and ice cover. Plants responded to the warmer temperatures with some of the earliest starts to spring in the record over Europe—one to two weeks earlier than the 2000–20 baseline—and a warm autumn resulted in a much longer leaf-on season. Severe wildfire seasons occurred in South America (the worst since 2010), Canada (for the second consecutive year), and the Arctic, contributing to the second-highest atmospheric carbon monoxide concentrations since 2003 and the highest tropospheric aerosol optical depth since 2019, at 550 nm.
This year’s iteration of the Global Climate chapter features two Sidebars, both of which present new topics that have not yet been explored in the report. The first covers the ability of satellite products to monitor changes in land surface temperature extremes and identify hotspots where regions of Earth are becoming uninhabitable. This Sidebar also discusses the importance of dataset stability for climate studies, as well as the correlation of land surface temperature and air temperature anomalies. The second Sidebar complements the section on greenhouse gas concentrations by examining short-lived climate forcers—compounds that have lifetimes ranging from a few hours to a few decades.
As usual in the Global Climate chapter, Plate 2.1 shows maps of global annual anomalies for many of the variables and metrics presented herein. Many of these variables are also presented as time series in Plate 1.1. Most sections now use the 1991–2020 climatological reference period, in line with the World Meteorological Organization’s (WMO) recommendations, although this reference period is not possible for all datasets due to their length or legacy processing methods.
2025
2025
2025
2025
Genotoxicity assessment is essential for ensuring chemical safety and mitigating risks to human health and the environment. Traditional methods, reliant on animal models, are time-consuming, costly, and raise ethical concerns. New Approach Methods (NAMs) offer innovative, cost-effective, and ethical alternatives, playing a pivotal role in both traditional and next-generation risk assessment (NGRA) by minimizing the need for animal testing, particularly in genotoxicity evaluations. However, the development of NAMs often overlooks the particular physicochemical properties of nanomaterials (NMs), which significantly influence their toxicological behaviour and can interfere with genotoxicity evaluation. This underscores an urgent need for the standardization and adaptation of NAMs to address nano- and advanced material-specific genotoxicity challenges. In this review, we summarize the challenges associated with genotoxicity testing of NMs and highlight the suitability of existing in vitro and in silico NAMs for NMs and advanced materials, enabling genotoxicity testing across various exposure routes and organ systems. Despite considerable progress, regulatory validation remains constrained by the absence of approved test guidelines and standardized protocols. To achieve regulatory acceptance, it is crucial to adapt NAMs to NM-specific exposure scenarios, refine test systems to better mimic human biology, develop tailored in vitro protocols, and ensure thorough characterisation of NMs both in pristine form and dispersed in culture medium. Collaborative efforts among scientists, regulators, industry, and advocacy groups are vital to improving the reliability and regulatory acceptance of NAMs. By addressing these challenges, NAMs have the potential to revolutionize genotoxicity risk assessment, advancing it towards a more sustainable, efficient and ethical framework.
2025
A Nano Risk Governance Portal supporting risk governance of nanomaterials and nano-enabled products
isk governance (RG) of nanomaterials (NMs) has been at the focus of the Horizon 2020 Programme of the European Union, through the funding of three research projects (Gov4Nano, NANORIGO, RISKGONE). The extensive collaboration of the three projects, in various scientific topics, aimed to enhance RG of NMs and provide a solid scientific basis for effective collaboration of the various types of stakeholders involved. In this paper the development of a digital Nano Risk Governance Portal (NRGP) and associated information technology (IT) infrastructure supporting the risk governance of (engineered) nanomaterials and nano-enabled products, is presented, alongside considerations for future work and enhancement within the domain of Advanced Materials (AdMa). This paper describes several elements of this digital portal, which serves as a single-entry point for all stakeholders in need of, or interested in, nano-risk governance aspects. In its simplest form, the NRGP allows users to be efficiently guided towards tailored information about nanomaterials, risk governance concepts, guidance documents, harmonized methods for risk assessment, publicly accessible data, information and knowledge, as well as a directory of tools, to assess the exposure and hazard of nanomaterials and perform Safe-and-Sustainable-by-Design (SSbD) assessment in the context of nano-risk governance. This paper presents the technical implementation and the content of the first version of the NRGP alongside the vision for the future and further plans for development, implementation, hosting and maintenance of the NRGP aimed at ensuring its sustainability. This includes a procedure to link to, or include, currently available and future (nano)material-related (cloud) platforms, decision support systems, tools, guidance, and databases in line with good governance objectives.
2025
CAMS Assessment Report on European Air Quality 2024
The full report provides reference information on air quality in Europe in 2024. The purpose of the report is to present a consistent and accurate estimate of European air quality focusing on key indicators and on the origin of selected pollution episodes. It is intended to support air quality experts in their reporting under air quality legislation by providing an overview over the status of European transboundary air pollution. It contains updated information on key indicators for background air quality for the main regulatory pollutants: ozone (O3), nitrogen dioxide (NO2), particulate matter of 10 micrometres or less in diameter (PM10) and particulate matter of 2.5 micrometres or less in diameter (PM2.5).
Copernicus Atmosphere Monitoring Service (CAMS)
2025
Alarmerende funn: Advarer: - Om dette fortsetter blir det ille
Metanutslipp på Svalbard øker i takt med et varmere klima. Nå advarer forskerne om at utslippene vil kunne overstige olje- og energisektoren.
2025
Fine particulate matter (PM) poses a major threat to public health, with organic aerosol (OA) being a key component. Major OA sources, hydrocarbon-like OA (HOA), biomass burning OA (BBOA), and oxygenated OA (OOA), have distinct health and environmental impacts. However, OA source apportionment via positive matrix factorization (PMF) applied to aerosol mass spectrometry (AMS) or aerosol chemical speciation monitoring (ACSM) data is costly and limited to a few supersites, leaving over 80% of OA data uncategorized in global monitoring networks. To address this gap, we trained machine learning models to predict HOA, BBOA, and OOA using limited OA source apportionment data and widely available organic carbon (OC) measurements across Europe (2010–2019). Our best performing model expanded the OA source data set 4-fold, yielding 85 000 daily apportionment values across 180 sites. Results show that HOA and BBOA peak in winter, particularly in urban areas, while OOA, consistently the dominant fraction, is more regionally distributed with less seasonal variability. This study provides a significantly expanded OA source data set, enabling better identification of pollution hotspots and supporting high-resolution exposure assessments.
2025