Publications

ExSIRA - Experimental Study to Investigate Risk of selected Amines "Fly me to the moon". NILU F

Velken, A.v.S.

ExSIRA - Experimental study to investigate risk of selected amines (project no. 199874/S60). NILU PP

Berglen, T.F.; ExSIRA project team.

Extending the long-term record of volcanic SO2 emissions with the Ozone Mapping and Profiler Suite nadir mapper.

Carn, S. A.; Yang, K.; Prata, A. J.; Krotkov, N. A.

Extensive reduction of surface UV radiation since 1750 in world's populated regions.

Kvalevåg, M.M.; Myhre, G.; Myhre, C.L.

Extracellular Vesicles as Next-Generation Diagnostics and Advanced Therapy Medicinal Products

Stawarska, Agnieszka; Bamburowicz-Klimkows, Magdalena; Rundén-Pran, Elise; Dusinska, Maria; Cimpan, Mihaela Roxana; Rios Mondragon, Ivan; Grudzinski, Ireneusz P.

Extracellular vesicles (EVs) hold great promise for clinical application as new diagnostic and therapeutic modalities. This paper describes major GMP-based upstream and downstream manufacturing processes for EV large-scale production, also focusing on post-processing technologies such as surface bioengineering and uploading studies to yield novel EV-based diagnostics and advanced therapy medicinal products. This paper also focuses on the quality, safety, and efficacy issues of the bioengineered EV drug candidates before first-in-human studies. Because clinical trials involving extracellular vesicles are on the global rise, this paper encompasses different clinical studies registered on clinical-trial register platforms, with varying levels of advancement, highlighting the growing interest in EV-related clinical programs. Navigating the regulatory affairs of EVs poses real challenges, and obtaining marketing authorization for EV-based medicines remains complex due to the lack of specific regulatory guidelines for such novel products. This paper discusses the state-of-the-art regulatory knowledge to date on EV-based diagnostics and medicinal products, highlighting further research and global regulatory needs for the safe and reliable implementation of bioengineered EVs as diagnostic and therapeutic tools in clinical settings. Post-marketing pharmacovigilance for EV-based medicinal products is also presented, mainly addressing such topics as risk assessment and risk management.

MDPI

Extreme climate of the global troposphere and stratosphere in the 1940-42 related to El Nino.

Brönnimann, S.; Luterbacher, J.; Staehelin, J.; Svendby, T. M.; Hansen, G.; Svenøe, T.

Extreme precipitation event over North China in August 2010: observations, monthly forecasting, and link to intra-seasonal variability of the Silk-Road wave-train across Eurasia.

Orsolini, Y.; Zhang, L.; Peters, D.; Fraedrich, K.

Extreme precipitation events over north China in August 2010 and their link to eastward-propagating wave-trains across Eurasia: observations and monthly forecasting.

Orsolini, Y. J.; Zhang, L.; Peters, D. H. W.; Fraedrich, K.; Zhu, X.; Schneidereit, A.; van den Hurk, B.

Extreme stratospheric vortex events in the ECMWF seasonal forecast model with re-analyses

Orsolini, Yvan

EYE-CLIMA: A Horizon Europe project using atmospheric inversions to improve national estimates of greenhouse gas emissions

Winiwarter, Wilfried; Thompson, Rona Louise; Stohl, Andreas; Peylin, Philippe; Ciais, Philippe; Boesch, Hartmuth; Aalto, Tuula; Berchet, Antoine; Kanakidou, Maria; Peters, Glen Philip; Shchepashchenko, Dmitry; Chang, Jean-Pierre; Fuß, Roland; Pisso, Ignacio; Engelen, Richard; Arneth, Almuth; Buchmann, Nina; Reimann, Stefan; Platt, Stephen Matthew; Krishnankutty, Nalini

Eyjafjallajökull volcanic ash concentrations determined using Spin Enhanced Visible and Infrared Imager measurements.

Prata, A.J.; Prata, A.T.

Facing the challenges of the International Airways Volcano Watch: the 2004/05 eruptions of Manam, Papua New Guinea.

Tupper, A.; Itikarai, I.; Richards, M.S.; Prata, F.; Carn, S.; Rosenfeld, D.

Factors affecting bioaccumulation of cyclic volatile methyl siloxanes in a subarctic benthopelagic food web.

Krogseth, I. S.; Undeman, E.; Evenset, A.; Christensen, G. N.; Whelan, M. J.; Breivik, K.; Evenset, A.; Warner, N. A.