Skip to content
  • Submit

  • Category

  • Sort by

  • Per page

Found 10000 publications. Showing page 221 of 400:

Publication  
Year  
Category

In silico unravelling of descriptors for cytotoxicity and genotoxicity for hazard identification of nanomaterials

Yamani, Naouale El; Gromelski, Maciej; Mariussen, Espen; Wyrzykowska, E.; Grabarek, D.; Puzyn, Tomasz; Dusinska, Maria; Rundén-Pran, Elise

2021

In memory of Dr. Ir. Gudrun Koppen (1969–2024)

Collins, Andrew Richard Sherman; Azqueta, Oscoz Amaya; Schoeters, Greet; Slingers, Gitte; Dusinska, Maria; Langie, Sabine A.S.

2024

Improving Quality in Nanoparticle-Induced Cytotoxicity Testing by a Tiered Inter-Laboratory Comparison Study

Nelissen, Inge; Haase, Andrea; Anguissola, Sergio; Rocks, Louise; Jacobs, An; Willems, Hanny; Riebeling, Christian; Luch, Andreas; Piret, Jean-Pascal; Toussaint, Olivier; Trouiller, Benedicte; Lacroix, Ghislaine; Gutleb, Arno C.; Contal, Servane; Diabaté, Silvia; Weiss, Carsten; Lozano-Fernandez, Tamara; Gonzalez-Fernandez, Africa; Dusinska, Maria; Huk, Anna; Stone, Vicki; Kanase, Nilesh; Nocun, Marek; Stepnik, Maciej; Meschini, Stefania; Ammendolia, Maria Grazia; Lewinski, Nastassja; Riediker, Michael; Venturini, Marco; Benetti, Frederico; Topinka, Jan; Brzicova, Tana; Milani, Silvia; Rädler, Joachim; Salvati, Anna; Dawson, Kenneth A.

The quality and relevance of nanosafety studies constitute major challenges to ensure their key role as a supporting tool in sustainable innovation, and subsequent competitive economic advantage. However, the number of apparently contradictory and inconclusive research results has increased in the past few years, indicating the need to introduce harmonized protocols and good practices in the nanosafety research community. Therefore, we aimed to evaluate if best-practice training and inter-laboratory comparison (ILC) of performance of the 3-(4,5-dimethylthiazol-2-yl)-5-(3-carboxymethoxyphenyl)-2-(4-sulfophenyl)-2H-tetrazolium (MTS) assay for the cytotoxicity assessment of nanomaterials among 15 European laboratories can improve quality in nanosafety testing. We used two well-described model nanoparticles, 40-nm carboxylated polystyrene (PS-COOH) and 50-nm amino-modified polystyrene (PS-NH2). We followed a tiered approach using well-developed standard operating procedures (SOPs) and sharing the same cells, serum and nanoparticles. We started with determination of the cell growth rate (tier 1), followed by a method transfer phase, in which all laboratories performed the first ILC on the MTS assay (tier 2). Based on the outcome of tier 2 and a survey of laboratory practices, specific training was organized, and the MTS assay SOP was refined. This led to largely improved intra- and inter-laboratory reproducibility in tier 3. In addition, we confirmed that PS-COOH and PS-NH2 are suitable negative and positive control nanoparticles, respectively, to evaluate impact of nanomaterials on cell viability using the MTS assay. Overall, we have demonstrated that the tiered process followed here, with the use of SOPs and representative control nanomaterials, is necessary and makes it possible to achieve good inter-laboratory reproducibility, and therefore high-quality nanotoxicological data.

2020

Improving model simulations of volcanic emission clouds and assessing model uncertainties. Geophysical Monograph Series

Kristiansen, N. I.; Arnold, D.; Maurer, C.; Vira, J.; Radulescu, R.; Martin, D.; Stohl, A.; Stebel, K.; Sofiev, M.; O'Dowd, C.; Wotawa, G.

2016

Improving Estimates of Sulfur, Nitrogen, and Ozone Total Deposition through Multi-Model and Measurement-Model Fusion Approaches

Fu, Joshua S.; Carmichael, Gregory R.; Dentener, Frank; Aas, Wenche; Vestøl, Anna Camilla Andersson; Barrie, Leonard A.; Cole, AS; Galy-Lacaux, Corinne; Geddes, Jeffrey; Itahashi, Syuichi; Kanakidou, Maria; Labrador, Lorenzo; Paulot, Fabien; Schwede, Donna; Tan, Jiani; Vet, Robert

Earth system and environmental impact studies need high quality and up-to-date estimates of atmospheric deposition. This study demonstrates the methodological benefits of multimodel ensemble and measurement-model fusion mapping approaches for atmospheric deposition focusing on 2010, a year for which several studies were conducted. Global model-only deposition assessment can be further improved by integrating new model-measurement techniques, including expanded capabilities of satellite observations of atmospheric composition. We identify research and implementation priorities for timely estimates of deposition globally as implemented by the World Meteorological Organization.

2022

Improving Detection of Chemicals of Emerging Concern: Evaluation of Analytical Workflows and PikMe Prioritization in Wastewater and Indoor Dust

Rostkowski, Pawel; Gundersen, Cathrine Brecke; Froment, Jean Francois; Nikiforov, Vladimir; Reid, Malcolm James; Wennberg, Aina Charlotte

Suspect screening helps detect chemicals in environmental samples without predefined target lists which can facilitate isolation of a larger number of substances. This study shows however that no single extraction method or analytical platform (LC-HRMS or GC-HRMS) can capture all relevant pollutants—at least half are missed. The technique works best for chemically similar families, where optimized methods can target specific classes or broader families of similar substances (e.g. PFAS). Effective grouping of similar substances is therefore essential. A broad coverage of substances can however be achieved if multiple sample extractions are performed and each extract is analysed on both LC- and GC-HRMS. Strategies where comparisons can be made over time or across locations will also help to isolate pollutant-related signals from the background. Such considerations must be integrated into programme design and budgeting for retrospective analysis. This will maximize likelihood of detection for the largest diversity of substances.
Norwegian Environment Agency, M-3038|2025

NILU

2026

Improving data reliability in air quality monitoring from static and mobile sensor platforms and networks using the FILTER framework

Salamalikis, Vasileios; Hassani, Amirhossein; Schneider, Philipp; Castell, Nuria

The growing adoption of low-cost sensors (LCSs) has significantly enhanced environmental monitoring by enabling widespread, community-driven data collection, particularly in regions requiring dense monitoring, and in regions with limited or no reference instrumentation. Increased public awareness and demand for dense environmental monitoring have resulted in extensive air quality and meteorological datasets from diverse sources. However, the integration of such datasets into regulatory frameworks and large-scale environmental monitoring remains challenging due to persistent issues related to data quality, standardization, and interoperability. To address these challenges, the FILTER (Framework for Improving Low-cost Technology Effectiveness and Reliability) approach developed by Hassani et al. (2025) provides a suite of algorithms to harmonize, quality-check, flag, and perform in-situ corrections on crowdsourced PM2.5 LCS datasets. While FILTER was initially designed and validated for static PM2.5 sensors, it has since been extended to address data quality challenges associated with the dynamics of mobile and wearable sensing. Across both static and mobile LCS platforms, FILTER employs a unified processing pipeline that generates measurement-level quality flags based on multiple statistical tests, to quantify the reliability of each observation. Quality control (QC) includes statistical tests to: (a) assess physical measurement consistency (range validity test), (b) detect flatline behavior (constant value test), and (c) identify abnormal patterns (spatiotemporal outlier detection test) using both historical trends and spatial comparisons with neighboring LCSs. Beyond these mandatory QC steps, more advanced statistical procedures incorporate relative (spatial correlation test) and absolute (spatial similarity test) comparisons with nearby LCSs, higher-quality instruments, and reference monitoring stations. For mobile and wearable sensing, FILTER has been specifically adapted to support pairwise comparisons between mobile sensors and comparisons with higher-accuracy nodes, accounting for operation under dynamic environmental and operational conditions. In this context, statistical comparisons are evaluated during rendezvous events, that is, periods in which the mobile sensor and a higher-accuracy node provide temporally coincident measurements. The modified framework retains the core principles of transparency, scalability, and sensor independence, while introducing additional steps to address motion-related artifacts, intermittent time series, and location-specific uncertainties. FILTER is developed in the open-source R environment. Its modular and hierarchical design allows flexible adaptation of quality control and correction workflows based on data availability, the spatiotemporal characteristics of LCS networks, and application-specific requirements. By improving data reliability and usability, FILTER enables crowdsourced LCS datasets to serve as a reliable complement to official monitoring networks for air quality management, urban- and regional-scale modeling, and policymaking. References  Hassani, A., Salamalikis, V., Schneider, P., Stebel, K., and Castell, N.: A scalable framework for harmonizing, standardization, and correcting crowd-sourced low-cost sensor PM2. 5 data across Europe, J. Environ. Manage., 380, 125100, 2025. 

2026

Improvements in European mapping of NO2 and BaP concentrations and exposure.

Horálek, J.; de Smet, P, de Leeuw, F.; Kurfürst, P.; Benešová, N.; Schneider, P.; Guerreiro, C.

2017

Improvement of Norwegian monitoring infrastructures to meet future observational needs. NILU PP

Fjæraa, A.M.; Fiebig, M.; Aas, W.; Lunder, C.; Myhre, C.L.

2010

Improved source term estimation using blind outlier detection.

Martinez-Camara, M.; Haro, B.B.; Vetterli, M.; Stohl, A.

2014

Improved Representation of High Latitude Mineral Dust Sources in the NASA GEOS Model

Moore, Kathryn A.; Colarco, Peter Richard; Leung, Danny M.; Downey, Arnold; Hildebrand, Frederik; Buck, Cliff; Gaiero, Diego; Zwaaftink, Christine Groot; Zamora, Lauren M.; Joshi, Janak; King, James; Skov, Henrik; Marsay, Chris; Koffmann, Bess G.; Kaplan, Michael R.; Kok, Jasper F.

2025

Improved protection of paintings during exhibition, storage and transit - PROPAINT. NILU PP

Grøntoft, T.; Dahlin, E.; Odlyha, M.; Scharff, M.; Andrade, G.; Mottner, P.; Czop, J.; Colombini, P.

2007

Improved protection of paintings during exhibition, storage and transit - PROPAINT (EU project FP6, 044254).

Grøntoft, T.; Dahlin, E.; Odlyha, M.; Scharff, M.; Andrade, G.; Mottner, P.; Czop, J.; Colombini, P.; Hackney, S.; Wadum, J.

2007

Improved optical flow velocity analysis in SO2 camera images of volcanic plumes – implications for emission-rate retrievals investigated at Mt Etna, Italy and Guallatiri, Chile

Gliss, Jonas; Stebel, Kerstin; Kylling, Arve; Sudbø, Aasmund

Accurate gas velocity measurements in emission plumes are highly desirable for various atmospheric remote sensing applications. The imaging technique of UV SO2 cameras is commonly used to monitor SO2 emissions from volcanoes and anthropogenic sources (e.g. power plants, ships). The camera systems capture the emission plumes at high spatial and temporal resolution. This allows the gas velocities in the plume to be retrieved directly from the images. The latter can be measured at a pixel level using optical flow (OF) algorithms. This is particularly advantageous under turbulent plume conditions. However, OF algorithms intrinsically rely on contrast in the images and often fail to detect motion in low-contrast image areas. We present a new method to identify ill-constrained OF motion vectors and replace them using the local average velocity vector. The latter is derived based on histograms of the retrieved OF motion fields. The new method is applied to two example data sets recorded at Mt Etna (Italy) and Guallatiri (Chile). We show that in many cases, the uncorrected OF yields significantly underestimated SO2 emission rates. We further show that our proposed correction can account for this and that it significantly improves the reliability of optical-flow-based gas velocity retrievals.

In the case of Mt Etna, the SO2 emissions of the north-eastern crater are investigated. The corrected SO2 emission rates range between 4.8 and 10.7 kg s−1 (average of 7.1  ±  1.3 kg s−1) and are in good agreement with previously reported values. For the Guallatiri data, the emissions of the central crater and a fumarolic field are investigated. The retrieved SO2 emission rates are between 0.5 and 2.9 kg s−1 (average of 1.3  ±  0.5 kg s−1) and provide the first report of SO2 emissions from this remotely located and inaccessible volcano.

2018

Importance of integration and implementation of emerging and future mercury research into the Minamata convention.

Gustin, M.S.; Evers, D.C.; Bank, M.S.; Hammerschmidt, C.R.; Pierce, A.; Basu, N.; Blum, J.; Bustamante, P.; Chen, C.; Driscoll, C.T.; Horvat, M.; Jaffe, D.; Pacyna, J.; Pirrone, N.; Selin, N.

2016

Importance of diet in protection against oxidative damage.

Staruchova, M.; Volkovova, K.; Lajdova, A.; Mislanova, C.; Collins, A.; Wsolova, L.; Staruch, L.; Dusinska, M.

2006

Import, use, and emissions of PCBs in Switzerland from 1930 to 2100.

Glüge, J.; Steinlin, C.; Schalles, S.; Wegmann, L.; Tremp, J.; Breivik, K.; Hungerbühler, K.; Bogdal, C.

2017

Implications of Regurgitative Feeding on Plastic Loads in Northern Fulmars (Fulmarus glacialis): A Study from Svalbard

Tulatz, Felix; Gabrielsen, Geir Wing; Bourgeon, Sophie; Herzke, Dorte; Krapp, Rupert; Langset, Magdalene; Neumann, Svenja; Lippold, Anna; Collard, France

Procellariiform seabirds like northern fulmars (Fulmarus glacialis) are prone to ingest and accumulate floating plastic pieces. In the North Sea region, there is a long tradition to use beached fulmars as biomonitors for marine plastic pollution. Monitoring data revealed consistently lower plastic burdens in adult fulmars compared to younger age classes. Those findings were hypothesized to partly result from parental transfer of plastic to chicks. However, no prior study has examined this mechanism in fulmars by comparing plastic burdens in fledglings and older fulmars shortly after the chick-rearing period. Therefore, we investigated plastic ingestion in 39 fulmars from Kongsfjorden (Svalbard), including 21 fledglings and 18 older fulmars (adults/older immatures). We found that fledglings (50−60 days old) had significantly more plastic than older fulmars. While plastic was found in all fledglings, two older fulmars contained no and several older individuals barely any plastic. These findings supported that fulmar chicks from Svalbard get fed high quantities of plastic by their parents. Adverse effects of plastic on fulmars were indicated by one fragment that perforated the stomach and possibly one thread perforating the intestine. Negative correlations between plastic mass and body fat in fledglings and older fulmars were not significant.

2023

Publication
Year
Category