Found 10001 publications. Showing page 372 of 401:
Toward Standardization of a Lung New Approach Model for Toxicity Testing of Nanomaterials
This study represents an attempt toward the standardization of pulmonary NAMs and the development of a novel approach for toxicity testing of nanomaterials. Laboratory comparisons are challenging yet essential for identifying existing limitations and proposing potential solutions. Lung cells cultivated and exposed at the air-liquid interface (ALI) more accurately represent the physiology of human lungs and pulmonary exposure scenarios than submerged cell and exposure models. A triculture cell model system was used, consisting of human A549 lung epithelial cells and differentiated THP-1 macrophages on the apical side, with EA.hy926 endothelial cells on the basolateral side. The cells were exposed to silver nanoparticles NM-300K for 24 h. The model used here showed to be applicable for assessing the hazards of nanomaterials and chemicals, albeit with some limitations. Cellular viability was measured using the alamarBlue assay, DNA damage was assessed with the enzyme-modified comet assay, and the expression of 40 genes related to cell viability, inflammation, and DNA damage response was evaluated through RT2 gene expression profiling. Despite harmonized protocols used in the two independent laboratories, however, some methodological challenges could affect the results, including sensitivity and reproducibility of the model.
2024
2008
2017
Phosphorus is a building block for all life and therefore plays an essential role in food production. Currently, large amounts of phosphorus enter the Norwegian food system from abroad in the form of mineral fertilizer, feedstuff, food, as well as micro-ingredients for animal feed, mainly in salmon farming. However, only a small fraction of this phosphorus ends up as food for humans, while the largest part accumulates in soil and water systems. This inefficiency entails two challenges:
1. Phosphorus supply is critical. Phosphate rock, the primary source of phosphorus for fertilizer and micro-ingredient production, is a limited resource that is highly concentrated in a few countries. Over 80% of global phosphate rock reserves are found in only 5 countries, and ~70% are located in Morocco and Morocco-occupied Western Sahara. The high concentration renders many countries vulnerable to geopolitical and economic instabilities and threatens food safety. The EU has therefore included phosphate rock on its list of Critical Raw Materials.
2. The accumulation of phosphorus in water systems can lead to eutrophication and dead zones, threatening fish stocks and other aquatic life. The high phosphorus concentration in soils due to overfertilization over long periods of time increases the danger of losses to water systems by runoff, further exacerbating the eutrophication risk.
A more circular use of phosphorus could simultaneously reduce supply and pollution risks. This is particularly relevant in Norway, where the government has an ambition to increase salmon and trout production from currently 1,5 to 5 million tons by 2050.
Achieving a circular phosphorus economy is a complex task: (i) The land- and the sea-based food systems are increasingly interlinked, for example through agricultural production of fish feed or the application of fish sludge on agricultural land. (ii) The Norwegian phosphorus cycle is increasingly interlinked with that of other countries as trade flows along the entire food supply chain are growing. (iii) Phosphorus fertilizers, both primary and recycled, are often contaminated with heavy metals such as cadmium, uranium, and zinc, which tend to accumulate in soils. Cleaning the phosphorus cycle is therefore vital for soil fertility and human health.
This report is based on the MIND-P project, which studied the Norwegian phosphorus cycle for both agriculture and aquaculture at a farm-by-farm basis and explored options for increasing circularity. The project identified farm-level and structural barriers to managing phosphorus resources more effectively.
We propose four fundamental strategies to overcome these barriers:
1. Develop and maintain a national nutrient accounting.
2. Minimize phosphorus losses and accumulations at farm level.
3. Establish infrastructures for capturing, processing, trade, and use of manure and fish sludge to produce high-quality recycled fertilizers that are tailored to the needs of the users in Norway and abroad.
4. Adopt a regulatory framework to promote a market for recycled fertilizer.
The strategies proposed here were developed with the support of an Advisory Panel consisting of representatives from government, industry, industry associations, and NGOs in an online and two physical workshops conducted in 2022.
Norges teknisk-naturvitenskapelige universitet
2023
2008
2013
2002
2002
2007
This report summaries the outcome of a workshop focused on standardizing monitoring strategies for Chemicals of Emerging Concern (CECs), including PFAS, flame retardants, chlorinated paraffins, siloxanes, and microplastics. Key recommendations include harmonised sampling methods, expanding the monitoring programs, conducting measurement campaigns, and enhancing analysis techniques.
NILU
2024
Towards a modelling network in support of the new air quality directive. Powerpoint presentation. NILU F
2007
2017
2015
2013
2013
2024
Towards a remote-sensing-driven model of isoprene emissions from Alpine tundra
Abstract This study investigates isoprene emissions in a high-latitude Alpine tundra ecosystem, focusing on using near-field remote sensing of surface temperatures, the photochemical reflectance index (PRI) and normalized difference vegetation index (NDVI), and meteorological measurements to model these emissions. Isoprene is a key biogenic volatile organic compound (BVOC) emitted by select plants, which can impact atmospheric chemistry and climate. Increased temperatures, particularly in high latitudes, may enhance isoprene emissions due to extended growing seasons and heightened plant stress. The research was conducted in Finse, Norway, where isoprene and CO 2 fluxes were measured with eddy covariance alongside spectral and meteorological data, and surface temperature. A random forest (RF) model was developed to predict isoprene fluxes, considering the variable importance of different environmental factors. The results showed that surface temperature and CO 2 flux were consistently important predictors, across three differential temporal data aggregations (hourly, daily, weekly), while the PRI demonstrated low predictive power, possibly due to the heterogeneous vegetation and variable light conditions. The NDVI was more effective than anticipated, likely linked to phenological changes in vegetation. Model performance varied with temporal resolution, with weekly data achieving the highest predictive accuracy ( R 2 up to 0.76). The RF model accurately reflected seasonal emission patterns but underestimated short-term peaks, suggesting the potential to combine machine learning with process-based modelling. This research highlights the promise of proxy data from remote sensing for scaling BVOC emission models to regional levels, essential for understanding climate impacts in Arctic ecosystems.
2025
2015
2019