Found 10463 publications. Showing page 390 of 419:
2011
The comet assay is one of the most popular tests for genotoxicity in cell cultures, non-animal species, animals and humans. It has high sensitivity to detect low levels of DNA damage, can be applied to non-proliferating cells, requires relatively few cells, is technically simple, and is low cost. The Organisation for Economic Co-operation and Development (OECD) adopted in 2016 the in vivo comet assay for measurement of DNA strand breaks in animal tissues. There is a desire to expand the comet assay to genotoxicity testing in cell cultures, including the detection of oxidatively damaged DNA by incubation of gel-embedded nucleoids with DNA repair enzymes, especially formamidopyrimidine DNA glycosylase (Fpg) which converts oxidised purines to DNA breaks. Based on available information in the literature, this review provides a retrospective evaluation of the validation status of this assay, focusing on accuracy and reliability in genotoxicity testing in vitro. Information on accuracy is scarce, although limited evidence suggests levels of Fpg-sensitive sites are similar to those obtained by Fpg-linked alkaline unwinding and alkaline elution assays. Several ring studies have shown that estimated background levels of DNA breaks vary within and between laboratories. However, ring studies indicate good intra- and inter-laboratory reproducibility of the standard assay on ionizing radiation-exposed and the Fpg-linked assay on potassium bromate exposed cells. Further studies are needed to assess the reproducibility in multiple laboratories using coded samples of non-genotoxins and genotoxins. Nevertheless, the available results indicate the comet assay is a reliable in vitro genotoxicity test.
2026
2017
2015
2018
Towards an integrated data-driven infrastructure (InfraNor)
The Arctic is warming almost four times faster compared to the rest of the world (Rantanen et al. 2022). Svalbard and its surroundings have warmed faster than most of the Arctic (Cai et al. 2021; Isaksen et al. 2022). The Svalbard archipelago also shows large temperature variations from south to north and east to west (Østby et al. 2017). Svalbard has good infrastructure, logistics and communications (airport, port, laboratories), and excellent possibilities for data transfer. This makes Svalbard and its surroundings an attractive living natural laboratory for long-term and campaign-based Arctic studies.
2025
2013
2010
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2020
The main goal for the “Towards better exploitation of Satellite data for monitoring Air Quality in Norway using
downscaling techniques” (Sat4AQN) project was to evaluate the potential of spatially downscaling satellite data using a
high-resolution Chemical Transport Model (CTM) to spatial scales that are more relevant for monitoring air quality in
urban areas and regional background sites in Norway. For this demonstration project, we focused on satellite aerosol
optical density (AOD) and particulate matter (PM) estimates.
NILU
2020
2003
2015
2015
2018
Towards crowd-sourced air quality and physical activity monitoring by a low-cost mobile platform. Lecture Notes in Computer Science, 9677
2016
Towards Net Zero: Evaluating Combined Terrestrial and Marine CDR Approaches
With the global annual mean temperature in 2024 exceeding 1.5°C above preindustrial levels, there is an urgent need to investigate pathways for returning the Earth system to lower temperature levels. In addition to stringent emission reduction, we need portfolios of Carbon Dioxide Removal (CDR) techniques to achieve the net-zero emission target. Therefore, it is crucial to evaluate various land and ocean-based CDRs for their effectiveness, environmental risks, and additional benefits.
This study evaluates the CO₂ sequestration potential and efficacy of two prominent CDR methods—Bioenergy with Carbon Capture and Storage (BECCS) and Ocean Alkalinity Enhancement (OAE)—applied both individually and in combination. Using the Norwegian Earth System Model (NorESM2-LM), simulations were designed with ramped-up CDR deployment, targeting 5.2 million km² of bioenergy feedstock for BECCS and a CaO deployment rate of 2.7 Gt/year for OAE by 2100 across the exclusive economic zones of Europe, the United States, and China. The results reveal a nearly additive carbon removal effect of BECCS and OAE. Over the period 2030-2100, OAE sequestered a total of 7 ppm of CO2 with an accumulated 82.3 Gt CaO, achieving a CDR effectiveness of 0.08 ppm per Gt of CaO, while BECCS removes 23 ppm of CO2, with CDR effectiveness of 3.1 ppm per million km² of bioenergy crops. The combined BECCS-OAE simulation offsets anthropogenic CO₂ emissions of 5.4 Gt/year by 2100—equivalent to over 60% of current global transport sector emissions. However, the combined CDR scenario shows negligible effects on the global annual mean temperature, with no clear response detectable against the high internal variability. This underscores the limitations of current CDR approaches in addressing climate warming over the 21st century and emphasizes the need for substantial emissions reductions, supportive policies and diversified CDR strategies to facilitate a return to lower global temperatures.
2025
Bioaerosols interact with society and environment in a multi-faceted way. Information about biological aerosols in the atmosphere is at high demand for medical practitioners and allergy sufferers, climate change researchers, agriculture and forestry industries, air quality forecasters, a variety of information added-value businesses, and many other stakeholders. However, the monitoring practices established over 70 years ago and barely changed since then are country-specific, with varying data availability and usage policy. These roadblocks slow down cross-disciplinary research and development of measures to understand and, upon necessity, control societal and environmental impacts of bioaerosols.A series of technological breakthroughs during last 10 years introduced a variety of automatic particle counters capable of bioaerosol monitoring in real time. They paved the way to the volunteering consolidation of European aerobiologists to establish the EUMETNET AutoPollen Programme (www.autopollen.net), laid down the foundation for the bioaerosol monitoring infrastructure with the EU Horizon SYLVA project (A SYstem for reaL-time obserVation of Aeroallergens, https://sylva.bioaerosol.eu), initiated developments of European standards and guidelines for the automatic bioaerosol measurements with the EURAMET project BioAirMet, and started the European standardization effort with CEN WG 39.The new technologies allow to observe bioaerosol concentration in real time, analyze vertical concentration profiles via remote-sensing, perform metagenomic analysis of bioaerosols with the 3rd generation DNA sequencing technique, and combine these observations with atmospheric composition models. Newly established regional networks have been connected to regional atmospheric composition models, which assimilate the real-time regional data to improve the forecasts. It changes the existing paradigm of bioaerosol observations as the new monitoring networks involve large-scale data handling infrastructure, which also includes numerical models as an interface between the different technologies and a bridge to users of information.The new observations heavily rely on sophisticated technologies, such as high-resolution image analysis, holography, multi-band scatterometry and fluorescence spectrometry, lidar-based remote sensing, and nanotechnology for DNA sequencing. A particle recognition task, the key challenge for the new devices, is solved via machine learning approaches. Technological complexity of the new instruments and large amounts of raw data they produce have been recognized, and a European-scale solution has been proposed by AutoPollen/SYLVA. AutoPollen is being converted into a EUMETNET operational programme with the SYLVA infrastructure as its technological backbone. The programme, with support of Copernicus Atmosphere Monitoring Service (https://atmosphere.copernicus.eu), ACTRIS aerosol monitoring network, and other stakeholders, will become operational from 2027. The central processing system will be hosted by Finnish Meteorological Institute with support of MeteoSwiss, Technical University of Munich, and all SYLVA partners. The pre-operational work of AutoPollen/SYLVA started already in 2025, owing to the efforts of the SYLVA consortium, its sister projects and collaborators. The programme is open for all European (and from outside Europe) groups performing automatic bioaerosol monitoring. AutoPollen offers technological and organizational support, community-developed bioaerosol monitoring solutions, and a motivated team of experts advancing the relevant research and applications.
2026
Towards operational satellite based atmospheric monitoring in Norway SatMoNAir. NILU OR
The SatMoNAir project [NSC contract nr. JOP.12.12.2] builds on a previous NRS 'følgemiddel'-project, called `Roadmap towards EarthCARE and Sentinel 5 precursor', within which NILU and met.no developed a strategy for how best to prepare themselves for future European satellite missions for measuring atmospheric composition, with respect to their national monitoring, weather predictions and research tasks. Three specific topics were considered particularly relevant: a. Aerosols ¿Climate effects in Scandinavia and polar regions: analysis of episodes with high aerosol loads for Klif reporting, b. the Use of satellite based ozone measurements in national reporting, and c. Satellite based Air Quality monitoring of remote areas for EMEP reporting. Results from the work performed are described in this report. The outcomes of the project have been utilized in support of the National monitoring of greenhouse gases and aerosols (see Myhre et al., 2012), the atmospheric ozone layer (see Svendby et al., 2012), and have been reported to EMEP.
2013
2015