Publications

Nanomedicine and epigenetics: New alliances to increase the odds in pancreatic cancer survival

Urbanova, Maria; Cihova, Marina; Buocikova, Verona; Slopovsky, Jan; Dubovan, Peter; Pindak, Daniel; Tomas, Miroslav; García-Bermejo, Laura; Rodríguez-Garrote, Mercedes; Earl, Julie; Kohl, Yvonne; Kataki, Agapi; Dusinska, Maria; Sainz Jr., Bruno; Smolkova, Bozena; Gabelova, Alena

Pancreatic ductal adenocarcinoma (PDAC) is among the deadliest cancers worldwide, primarily due to its robust desmoplastic stroma and immunosuppressive tumor microenvironment (TME), which facilitate tumor progression and metastasis. In addition, fibrous tissue leads to sparse vasculature, high interstitial fluid pressure, and hypoxia, thereby hindering effective systemic drug delivery and immune cell infiltration. Thus, remodeling the TME to enhance tumor perfusion, increase drug retention, and reverse immunosuppression has become a key therapeutic strategy. In recent years, targeting epigenetic pathways has emerged as a promising approach to overcome tumor immunosuppression and cancer progression. Moreover, the progress in nanotechnology has provided new opportunities for enhancing the efficacy of conventional and epigenetic drugs. Nano-based drug delivery systems (NDDSs) offer several advantages, including improved drug pharmacokinetics, enhanced tumor penetration, and reduced systemic toxicity. Smart NDDSs enable precise targeting of stromal components and augment the effectiveness of immunotherapy through multiple drug delivery options. This review offers an overview of the latest nano-based approaches developed to achieve superior therapeutic efficacy and overcome drug resistance. We specifically focus on the TME and epigenetic-targeted therapies in the context of PDAC, discussing the advantages and limitations of current strategies while highlighting promising new developments. By emphasizing the immense potential of NDDSs in improving therapeutic outcomes in PDAC, our review paves the way for future research in this rapidly evolving field.

Elsevier

Nanoparticles (NPs): Influence on human health.

Liu, H.-Y.

Nanoparticles in food. Epigenetic changes induced by nanomaterials and possible impact on health.

Smolkova, B.; El Yamani, N.; Collins, A.R.; Gutleb, A.C.; Dusinska, M.

Nanoparticles: a hidden hazard?

Dusinska, M.; El Yamani, N.; Gabelova, A.; Alonso T. I.; Rundén-Pran, E.; Fjellsbø, L. M.; Silva, M. J.; Shaposhnikov, S.; Collins, A. R.

NANoREG framework for the safety assessment of nanomaterials. EUR 28550 EN

Gottardo, S.; Crutzen, H.; Jantunen, P. (eds.) Gottardo, S.; Alessandrelli, M.; Amenta, V.; Atluri, R.; Barberio, G.; Bekker, C.; Bergonzo, P.; Bleeker, E.; Booth, A. M.; Borges, T.; Buttol, P.; Carlander, D.; Castelli, S.; Chevillard, S.; Clavaguera, S.; Dekkers, S.; Delpivo, C.; Di Prospero Fanghella, P.; Dusinska, M.; Einola, J.; Ekokoski, E.; Fito, C.; Gouveia, H.; Grall, R.; Hoehener, K.; Jantunen, P.; Johanson, G.; Laux, P.; Lehmann, H. C.; Leinonen, R.; Mech, A.; Micheletti, C.; Noorlander, C.; Mattsson, M. O.; Oomen, A.; Pesudo, L. Q.; Polci, M. L.; Prina-Mello, A.; Rasmussen, K.; Rauscher, H.; Jimenez, A. S.; Sintes, J. R.; Scalbi, S.; Sergent, J.-A.; Stockmann-Juvala, H.; Simko, M.; Sips, A.; Suarez, B.; Sumrein, A.; van Tongeren, M.; Vázquez-Campos, S.; Vital, N.; Walser, T.; Wijnhoven, S.; Crutzen, H. (authors).

NanoReg2 - case study. Cytotoxicity- and genotoxicity-testing of silica nanomaterials prepared by Nanomakers.

Hudecova, Alexandra Misci; Mariussen, Espen; Dusinska, Maria; Rundén-Pran, Elise

NILU

Nanosafety: challenges and opportunities

Rundén-Pran, Elise

NanoSolveIT Project: Driving nanoinformatics research to develop innovative and integrated tools for in silico nanosafety assessment

Afantitis, Antreas; Melagraki, Georgia; Isigonis, Panagiotis; Tsoumanis, Andreas; Varsou, Dimitra Danai; Valsami-Jones, Eugenia; Papadiamantis, Anastasios; Ellis, Laura-Jayne; Sarimveis, Haralambos; Doganis, Philip; Karatzas, Pantelis; Tsiros, Periklis; Liampa, Irene; Lobaskin, Vladimir; Greco, Dario; Serra, Angela; Kinaret, Pia Anneli Sofia; Saarimaki, Laura Aliisa; Grafström, Roland; Kohonen, Pekka; Nymark, Penny; Willighagen, Egon; Puzyn, Tomasz; Rybinska-Fryca, Anna; Lyubartsev, Alexander; Jensen, Keld Alstrup; Brandenburg, Gerit; Lofts, Stephen; Svendsen, Claus; Harrison, Samuel; Maier, Dieter; Tamm, Kaido; Jänes, Jaak; Sikk, Lauri; Dusinska, Maria; Longhin, Eleonora Marte; Rundén-Pran, Elise; Mariussen, Espen; El Yamani, Naouale; Unger, Wolfgang; Radnik, Jörg; Tropsha, Alexander; Cohen, Yoram; Leszcynski, Jerzy; Hendren, Christine Ogilvie; Wiesner, Mark; Winkler, David; Suzuki, Noriyuki; Yoon, Tae Hyun; Choi, Jang-Sik; Sanabria, Natasha; Gulumian, Mary; Lynch, Iseult

Elsevier

Nanotechnology and Nanosafety. How to proceed?

EL Yamani, N.

NanoTEST. NILU PP

Fjellsbø, L.M.; Dusinska, M.; Tran, L.; Juillerat, L.; Marano, F.; Boland, S.; Saunders, M.; Whelan, M.; Housiadas, C.; Volkovova, K.; Tulinska, J.; Sebekova, K.; Knudsen, L.E.; Castell, J.V.; Vilà, M.; Gombau, L.; Pojana, G.; Marcomini, A.

Narrowband filter radiometer for ground-based measurements of global ultraviolet solar irradiance and total ozone.

Petkov, B.; Vitale, V.; Tomasi, C.; Bonafé, U.; Scaglione, S.; Flori, D.; Santaguida, R.; Gausa, M.; Hansen, G.; Colombo, T.

Nasjonalt samfunnsoppdrag om sirkulær økonomi. Forslag til organisering.

Möller, Charlotta; Tarrasón, Leonor; Guerreiro, Cristina

Denne rapporten inneholder forslag til organisering av et mulig nasjonalt samfunnsoppdrag om sirkulærøkonomien. Vårt forslag til organisering av et nasjonalt samfunnsoppdrag om sirkulær økonomi skiller seg noe fra eksisterende organisering av de to andre nasjonale samfunnsoppdragene i Norge i at den baserer seg på å etablere en omstillingslab. Omstillingslaben vil ha en rolle som likner på den «operativ gruppe» i de andre to nasjonale samfunnsoppdragene, men som er større i omfang, og har konkrete mål for oppfølgings- og medvirkningsprosesser mot målbar transformasjon.

NILU