Found 9764 publications. Showing page 145 of 391:
2015
Nanomedicine and epigenetics: New alliances to increase the odds in pancreatic cancer survival
Pancreatic ductal adenocarcinoma (PDAC) is among the deadliest cancers worldwide, primarily due to its robust desmoplastic stroma and immunosuppressive tumor microenvironment (TME), which facilitate tumor progression and metastasis. In addition, fibrous tissue leads to sparse vasculature, high interstitial fluid pressure, and hypoxia, thereby hindering effective systemic drug delivery and immune cell infiltration. Thus, remodeling the TME to enhance tumor perfusion, increase drug retention, and reverse immunosuppression has become a key therapeutic strategy. In recent years, targeting epigenetic pathways has emerged as a promising approach to overcome tumor immunosuppression and cancer progression. Moreover, the progress in nanotechnology has provided new opportunities for enhancing the efficacy of conventional and epigenetic drugs. Nano-based drug delivery systems (NDDSs) offer several advantages, including improved drug pharmacokinetics, enhanced tumor penetration, and reduced systemic toxicity. Smart NDDSs enable precise targeting of stromal components and augment the effectiveness of immunotherapy through multiple drug delivery options. This review offers an overview of the latest nano-based approaches developed to achieve superior therapeutic efficacy and overcome drug resistance. We specifically focus on the TME and epigenetic-targeted therapies in the context of PDAC, discussing the advantages and limitations of current strategies while highlighting promising new developments. By emphasizing the immense potential of NDDSs in improving therapeutic outcomes in PDAC, our review paves the way for future research in this rapidly evolving field.
Elsevier
2023
2010
2019
2009
1999
2007
Målinger i Lillestrøm sentrum for utredning av hovedkilder til svevestøvforurensning. NILU rapport
A measurement project to investigate the main pollutants that contribute to PM pollution in Lillestrøm was conducted during the period February - April 2017. The project was a collaborative research project with Skedsmo municipality. Measurements of particulate matter (PM2.5, PM10), light absorption of particles (black carbon, BC) and particle size distributions were conducted in Vollaparken in the centre of Lillestrøm. An important source of PM was combustion, i.e. diesel engines and wood burning. For PM10 also resuspension of road dust is an important contribution. During the measurement period, traffic emissions were the main contribution from combustion. It was relatively mild during the measurement period and stable inversion periods were not observed. Therefore, the contribution from wood burning was low and there were no pollution episodes due to accumulation of emissions.
2017