Publications

Potential use of CAMS modelling results in air quality mapping under ETC/ATNI

Horálek, Jan; Hamer, Paul David; Schreiberova, Marketa; Colette, Augustin; Schneider, Philipp; Malherbe, Laure

ETC/ATNI

Precentation of recent EMEP activities. NILU F

Tørseth, K.

Preclinical validation of human recombinant glutamate-oxaloacetate transaminase for the treatment of acute ischemic stroke

Pérez-Mato, María; Dopico-López, Antonio; Akkoc, Yunus; López-Amoedo, Sonia; Correa-Paz, Clara; Candamo-Lourido, María; Iglesias-Rey, Ramón; López-Arias, Esteban; Bugallo-Casal, Ana; da Silva-Candal, Andrés; Bravo, Susana B.; Chantada-Vázquez, María del Pilar; Arias, Susana; Santamaría-Cadavid, María; Estany-Gestal, Ana; Zaghmi, Ahlem; Gauthier, Marc A.; Gutiérrez-Fernández, María; Martin, Abraham; Llop, Jordi; Rodríguez, Cristina; Almeida, Ángeles; Migliavacca, Martina; Polo, Ester; Pelaz, Beatriz; Gozuacik, Devrim; El Yamani, Naouale; Sengupta, Tanima; Rundén-Pran, Elise; Vivancos, José; Castellanos, Mar; Díez-Tejedor, Exuperio; Sobrino, Tomás; Rabinkov, Aharon; Mirelman, David; Castillo, José; Campos, Francisco

The blood enzyme glutamate-oxaloacetate transaminase (GOT) has been postulated as an effective therapeutic to protect the brain during stroke. To demonstrate its potential clinical utility, a new human recombinant form of GOT (rGOT) was produced for medical use.

We tested the pharmacokinetics and evaluated the protective efficacy of rGOT in rodent and non-human primate models that reflected clinical stroke conditions.

We found that continuous intravenous administration of rGOT within the first 8 h after ischemic onset significantly reduced the infarct size in both severe (30%) and mild lesions (48%). Cerebrospinal fluid and proteomics analysis, in combination with positron emission tomography imaging, indicated that rGOT can reach the brain and induce cytoprotective autophagy and induce local protection by alleviating neuronal apoptosis.

Our results suggest that rGOT can be safely used immediately in patients suspected of having a stroke. This study requires further validation in clinical stroke populations.

Predicting and validating the tracking of a volcanic ash cloud during the 2006 eruption of Mt. Augustine Volcano.

Webley, P.W.; Atkinson, D.; Collins, R.L.; Dean, K.; Fochesatto, J.; Sassen, K.; Cahill, C.F.; Prata, A.; Flynn, C.J.; Mizutani, K.

Predicting the effect of climate changes on the corrosion rate in coastal areas: The effect of extreme wind on sea salt aerosol deposition. Powerpoint presentation. NILU F

Svenningsen, G.; Grøntoft, T.

Predictors of per- and polyfluoroalkyl substances in a maternal population from Northern Norway.

Berg, V.; Nøst, T.H.; Huber, S.; Rylander, C.; Hansen, S.; Odland, J.Ø.; Sandanger, T.M.

Preface: Supplement on ELOISE II.

Pirrone, N.; Pacyna, J.M.; Munthe, J.; Barth, H.

Preliminary assessment of air quality in Norway (Phase 1), according to the new EU air quality directives. NILU OR

Larssen, S.; Hagen, L.O.; Tønnesen, D.

Preliminary assessment of air quality in Norway according to preliminary draft on EU air quality directive on heavy metals and BaP. NILU OR

Hagen, L.O.

Preliminary assessment report on the spatial mapping of air quality trends for Europe. ETC/ACC Tecnical paper, 2008/3

Denby, B.; Sundvor, I.; de Smet, P.; de Leeuw, F.

Preliminary evaluation of the relationship between IAQ and demand controlled ventilation.

Lopez-Aparicio, S.; Vogt, M.; Hak, C.; Dauge, F. R.; Holøs, S.; Mysen, M.

Preliminary results from the evaluation of the impact of bioethanol buses on urban air quality.

Lopez-Aparicio, S.; Hak, C.; Schmidbauer, N.; Dye, C.; Manø, S.