Found 10076 publications. Showing page 1 of 404:
New Approach Methodologies (NAMs) are gaining significant momentum globally to reduce animal testing and enhance the efficiency and human relevance of chemical safety assessment. Even with substantial EU commitment from regulatory agencies and the academic community, the full regulatory adoption of NAMs remains a distant prospect. This challenge is further complicated by the fact that the academic world, oriented toward NAMs development, and regulatory agencies, focused on practical application, frequently operate in separate spheres. Addressing this disconnect, the present paper, developed within the European Partnership for the Assessment of Risks from Chemicals (PARC), provides a clear overview of both the available non-animal tests and current evaluation practices for genotoxic and carcinogenic hazard assessment, while simultaneously highlighting existing regulatory needs, gaps, and challenges toward greater human health protection and the replacement of animal testing through NAMs adoption.
The analysis reveals a complex landscape: while the EU is deeply committed to developing and adopting NAMs, as outlined in its Chemical Strategy for Sustainability and supported by initiatives like PARC, prescriptive regulations such as Classification, Labelling and Packaging (CLP) and Registration, Evaluation, Authorisation and Restriction of Chemicals (REACH) still heavily mandate in vivo animal data for hazard classification, particularly for germ cell mutagenicity and carcinogenicity. This reliance creates a “too-short-blanket-problem,” where efforts to reduce animal testing may impact human health protection because of the current in vivo-based classification criteria. In contrast, sectors such as cosmetics and certain European Food Safety Authority (EFSA)-regulated products demonstrate greater flexibility toward progressive integration of NAMs. While the deep mechanistic understanding of genotoxicity and carcinogenicity has significantly advanced the integration of alternatives to animal tests into regulatory chemical hazard assessment, their broader and full implementation faces considerable challenges due to both scientific complexities (i.e., the development and validation of fit-for-purpose NAMs) and existing legislative provisions.
2026
Nitrogen dioxide (NO2) is a well-known air pollutant, mostly elevated by car traffic in cities. To date, small, reliable, cost-efficient multipollutant sensors with sufficient power and accuracy for community-based atmospheric studies are still lacking. The HAPADS (highly accurate and autonomous programmable platforms for providing air pollution data services) platforms, developed and tested in real conditions, can be a possible approach to solving this issue. The developed HAPADS platforms are equipped with three different NO2 sensors (7E4-NO2–5, SGX-7NO2, MICS-2711 MOS) and a combined ambient air temperature, humidity, and pressure sensor (BME280). The platforms were tested during the driving test, which was conducted across various roads, including highways, expressways, and national and regional routes, as well as major cities and the countryside, to analyse the environmental conditions as much as possible (Poland, 2024). The correlation coefficient r was more than 0.8, and RMSE (root mean squared error) was in the 3.3–4.3 μg/m3 range during the calibration process. The results obtained during the driving tests showed R2 of 0.9–1.0, which proves the ability of HAPADS platforms to work in the hard environmental conditions (including high rain and snow, as well as sun and a wide range of temperatures and humidity).
2026
Machine learning for mapping glacier surface facies in Svalbard
Glaciers are dynamic and highly sensitive indicators of climate change, necessitating frequent and precise monitoring. As Earth observation technology evolves with advanced sensors and mapping methods, the need for accurate and efficient approaches to monitor glacier changes becomes increasingly important. Glacier Surface Facies (GSF), formed through snow accumulation and ablation, serve as valuable indicators of glacial health. Mapping GSF provides insights into a glacier's annual adaptations. However, satellite-based GSF mapping presents significant challenges in terms of data preprocessing and algorithm selection for accurate feature extraction. This study presents an experiment using very high-resolution (VHR) WorldView-3 satellite data to map GSF on the Midtre Lovénbreen glacier in Svalbard. We applied three machine learning (ML) algorithms—Random Forest (RF), Artificial Neural Network (ANN), and Support Vector Machine (SVM)—to explore the impact of different image preprocessing techniques, including atmospheric corrections, pan sharpening methods, and spectral band combinations. Our results demonstrate that RF outperformed both ANN and SVM, achieving an overall accuracy of 85.02 %. However, nuanced variations were found for specific processing conditions and can be explored for specific applications. This study represents the first clear delineation of ML algorithm performance for GSF mapping under varying preprocessing conditions. The data and findings from this experiment will inform future ML-based studies aimed at understanding glaciological adaptations in a rapidly changing cryosphere, with potential applications in long-term spatiotemporal monitoring of glacier health.
2025
2025
2025
Støvnedfall Miljøbriketter AS. Måling av nedfallsstøv og mangan
NILU har gjort målinger av nedfallsstøv rundt Miljøbriketter AS sitt anlegg i Skien. Det ble gjort prøvetaking ved 8 målepunkter i to perioder. Prøvene ble analysert for mengde nedfallsstøv og mangan. Bidraget fra Miljøbriketter til total mengde nedfallsstøv er lite.
NILU
2025
2025
Monitoring of greenhouse gases and aerosols at Svalbard and Birkenes in 2024. Annual report
This annual report for 2024 summarizes the activities and results of the greenhouse gas monitoring at the Zeppelin Observatory, situated on Svalbard, during the period 2001-2024, and the greenhouse gas monitoring and aerosol observations from Birkenes for 2009-2024.
NILU
2025
Killer whales (Orcinus orca) accumulate high levels of persistent organic pollutants (POPs), which have been linked to immunomodulation. Over the past decades, large-scale mortality events associated with cetacean morbillivirus (CeMV) have affected cetacean populations, and concerns have been raised about the role of contaminants in exacerbating these outbreaks. However, establishing cause-effect relationships in free-roaming cetaceans remains a significant challenge. In vitro approaches present unique potential for furthering our understanding of the effects of multiple environmental stressors in marine mammal health. In this study, we used primary fibroblasts cultured from wild Norwegian killer whale skin biopsies (n = 6) to assess how exposure to POP mixtures affects cell viability and CeMV replication. Our findings demonstrate that CeMV successfully replicates in killer whale fibroblasts, with the viral replication significantly increasing over the duration of the experiment. POP exposure led to a concentration-dependent decrease in cell viability and a significant increase in viral replication. These results validate killer whale primary fibroblasts as a valuable in vitro tool for the study of co-exposure of POPs and morbillivirus on toothed cetaceans. Moreover, these findings support the need for further research to confirm the role of contaminants in intensifying the severity of CeMV infections in the wild.
2025
2025
2025
2025
Rethinking Global Soil Degradation: Drivers, Impacts, and Solutions
Abstract The increasing threat of soil degradation presents significant challenges to soil health, especially within agroecosystems that are vital for food security, climate regulation, and economic stability. This growing concern arises from intricate interactions between land use practices and climatic conditions, which, if not addressed, could jeopardize sustainable development and environmental resilience. This review offers a comprehensive examination of soil degradation, including its definitions, global prevalence, underlying mechanisms, and methods of measurement. It underscores the connections between soil degradation and land use, with a focus on socio‐economic consequences. Current assessment methods frequently depend on insufficient data, concentrate on singular factors, and utilize arbitrary thresholds, potentially resulting in misclassification and misguided decisions. We analyze these shortcomings and investigate emerging methodologies that provide scalable and objective evaluations, offering a more accurate representation of soil vulnerability. Additionally, the review assesses both physical and biological indicators, as well as the potential of technologies such as remote sensing, artificial intelligence, and big data analytics for enhanced monitoring and forecasting. Key factors driving soil degradation, including unsustainable agricultural practices, deforestation, industrial activities, and extreme climate events, are thoroughly examined. The review emphasizes the importance of healthy soils in achieving the United Nations Sustainable Development Goals, particularly concerning food and water security, ecosystem health, poverty alleviation, and climate action. It suggests future research directions that prioritize standardized metrics, interdisciplinary collaboration, and predictive modeling to facilitate more integrated and effective management of soil degradation in the context of global environmental changes.
2025
2025
Measurements from the Advanced Global Atmospheric Gases Experiment (AGAGE) combined with a global 12-box model of the atmosphere have long been used to estimate global emissions and surface mean mole fraction trends of atmospheric trace gases. Here, we present annually updated estimates of these global emissions and mole fraction trends for 42 compounds through 2023 measured by the AGAGE network, including chlorofluorocarbons, hydrochlorofluorocarbons, hydrofluorocarbons, perfluorocarbons, sulfur hexafluoride, nitrogen trifluoride, methane, nitrous oxide, and selected other compounds. The data sets are available at https://doi.org/10.5281/zenodo.15372480 (Western et al., 2025). We describe the methodology to derive global mole fraction and emissions trends, which includes the calculation of semihemispheric monthly mean mole fractions, the mechanics of the 12-box model and the inverse method that is used to estimate emissions from the observations and model. Finally, we present examples of the emissions and mole fraction data sets for the 42 compounds.
2025